Tag : Fluorescence imaging

Biology

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Newsemia
by Iker Lamas, Laura Merlini, Aleksandar Vještica, Vincent Vincenzetti, Sophie G. Martin Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas...
Biology

Image-based analysis of living mammalian cells using label-free 3D refractive index maps reveals new organelle dynamics and dry mass flux

Newsemia
by Patrick A. Sandoz, Christopher Tremblay, F. Gisou van der Goot, Mathieu Frechin Holo-tomographic microscopy (HTM) is a label-free microscopy method reporting the fine changes...
Biology

SorCS1-mediated sorting in dendrites maintains neurexin axonal surface polarization required for synaptic function

Newsemia
by Luís F. Ribeiro, Ben Verpoort, Julie Nys, Kristel M. Vennekens, Keimpe D. Wierda, Joris de Wit The pre- and postsynaptic membranes comprising the synaptic...
Biology

Reticulon and CLIMP-63 regulate nanodomain organization of peripheral ER tubules

Newsemia
by Guang Gao, Chengjia Zhu, Emma Liu, Ivan R. Nabi The endoplasmic reticulum (ER) is an expansive, membrane-enclosed organelle composed of smooth peripheral tubules and...
Biology

Astroglial dysfunctions drive aberrant synaptogenesis and social behavioral deficits in mice with neonatal exposure to lengthy general anesthesia

Newsemia
by Bin Zhou, Lingmin Chen, Ping Liao, Lu Huang, Zhuo Chen, Daqing Liao, Linghui Yang, Jing Wang, Guoqiang Yu, Li Wang, Jianguo Zhang, Yunxia Zuo,...
Biology

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

Newsemia
by Melissa Birol, Slawomir P. Wojcik, Andrew D. Miranker, Elizabeth Rhoades Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression...
Biology

Differential role of pre- and postsynaptic neurons in the activity-dependent control of synaptic strengths across dendrites

Newsemia
by Mathieu Letellier, Florian Levet, Olivier Thoumine, Yukiko Goda Neurons receive a large number of active synaptic inputs from their many presynaptic partners across their...
Biology

A small proportion of Talin molecules transmit forces at developing muscle attachments in vivo

Newsemia
by Sandra B. Lemke, Thomas Weidemann, Anna-Lena Cost, Carsten Grashoff, Frank Schnorrer Cells in developing organisms are subjected to particular mechanical forces that shape tissues...
Biology

Direct visualization of single-molecule membrane protein interactions in living cells

Newsemia
by Do-Hyeon Kim, Soyeon Park, Dong-Kyun Kim, Min Gyu Jeong, Jungeun Noh, Yonghoon Kwon, Kai Zhou, Nam Ki Lee, Sung Ho Ryu Interactions between membrane...
Biology

Protein aggregates encode epigenetic memory of stressful encounters in individual <i>Escherichia coli</i> cells

Newsemia
by Sander K. Govers, Julien Mortier, Antoine Adam, Abram Aertsen Protein misfolding and aggregation are typically perceived as inevitable and detrimental processes tied to a...
Biology

Protein aggregates encode epigenetic memory of stressful encounters in individual <i>Escherichia coli</i> cells

Newsemia
by Sander K. Govers, Julien Mortier, Antoine Adam, Abram Aertsen Protein misfolding and aggregation are typically perceived as inevitable and detrimental processes tied to a...

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