Tag : Flow cytometry

Biology

Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity

Newsemia
by Tony Ngo, Bryan S. Stephens, Martin Gustavsson, Lauren G. Holden, Ruben Abagyan, Tracy M. Handel, Irina Kufareva Chemokines and their receptors are orchestrators of...
Biology

IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics

Newsemia
by Candelas Álvarez-Salamero, Raquel Castillo-González, Gloria Pastor-Fernández, Isabel R. Mariblanca, Jesús Pino, Danay Cibrian, María N. Navarro Interleukin 23 (IL-23) triggers pathogenic features in pro-inflammatory,...
Biology

Yap suppresses T-cell function and infiltration in the tumor microenvironment

Newsemia
by Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas A major challenge for cancer immunotherapy is sustaining T-cell...
Biology

A new branched proximity hybridization assay for the quantification of nanoscale protein–protein proximity

Newsemia
by Shuangshuang Zheng, Melanie Sieder, Michael Mitterer, Michael Reth, Marco Cavallari, Jianying Yang Membrane proteins are organized in nanoscale compartments. Their reorganization plays a crucial...
Latest News

Streamlining Immuno-Oncological Therapeutic Antibody Discovery

Newsemia
The growing trend of implementing immunotherapy into oncology has resulted in various new therapeutic cancer treatments utilizing antibodies. Source link...
Biology

NLRX1 inhibits the early stages of CNS inflammation and prevents the onset of spontaneous autoimmunity

Newsemia
by Marjan Gharagozloo, Shaimaa Mahmoud, Camille Simard, Kenzo Yamamoto, Diwakar Bobbala, Subburaj Ilangumaran, Matthew D. Smith, Albert Lamontagne, Samir Jarjoura, Jean-Bernard Denault, Véronique Blais, Louis...
Biology

Adult bone marrow progenitors become decidual cells and contribute to embryo implantation and pregnancy

Newsemia
by Reshef Tal, Shafiq Shaikh, Pallavi Pallavi, Aya Tal, Francesc López-Giráldez, Fang Lyu, Yuan-Yuan Fang, Shruti Chinchanikar, Ying Liu, Harvey J. Kliman, Myles Alderman III,...
Biology

TSC1/mTOR-controlled metabolic–epigenetic cross talk underpins DC control of CD8<sup>+</sup> T-cell homeostasis

Newsemia
by Lei Shi, Xia Chen, Aiping Zang, Tiantian Li, Yanxiang Hu, Shixin Ma, Mengdie Lü, Huiyong Yin, Haikun Wang, Xiaoming Zhang, Bei Zhang, Qibin Leng,...
Biology

Attenuation of chronic antiviral T-cell responses through constitutive COX2-dependent prostanoid synthesis by lymph node fibroblasts

Newsemia
by Karin Schaeuble, Hélène Cannelle, Stéphanie Favre, Hsin-Ying Huang, Susanne G. Oberle, Daniel E. Speiser, Dietmar Zehn, Sanjiv A. Luther Lymphoid T-zone fibroblastic reticular cells...
Biology

Mouse HSA<sup>+</sup> immature cardiomyocytes persist in the adult heart and expand after ischemic injury

Newsemia
by Mariana Valente, Tatiana Pinho Resende, Diana Santos Nascimento, Odile Burlen-Defranoux, Francisca Soares-da-Silva, Benoit Dupont, Ana Cumano, Perpétua Pinto-do-Ó The assessment of the regenerative capacity...
Biology

Regulation of membrane phospholipid asymmetry by Notch-mediated flippase expression controls the number of intraepithelial TCRαβ<sup>+</sup>CD8αα<sup>+</sup> T cells

Newsemia
by Chieko Ishifune, Shin-ichi Tsukumo, Yoichi Maekawa, Katsuto Hozumi, Doo Hyun Chung, Chihiro Motozono, Sho Yamasaki, Hiroyasu Nakano, Koji Yasutomo Intestinal intraepithelial lymphocytes (IELs) expressing...
Biology

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

Newsemia
by Christopher J. Shoemaker, Tina Q. Huang, Nicholas R. Weir, Nicole Polyakov, Sebastian W. Schultz, Vladimir Denic The power of forward genetics in yeast is...
Biology

Uncovering and resolving challenges of quantitative modeling in a simplified community of interacting cells

Newsemia
by Samuel F. M. Hart, Hanbing Mi, Robin Green, Li Xie, Jose Mario Bello Pineda, Babak Momeni, Wenying Shou Quantitative modeling is useful for predicting...
Biology

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

Newsemia
by Branislav Ivan, Zhaozhi Sun, Harini Subbaraman, Nikolas Friedrich, Alexandra Trkola During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env)...

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