FirstLine

Nivolumab combined with ipilimumab safe as first-line therapy for lung cancer patients

Combining the PD-1 immune check point inhibitor nivolumab with the monoclonal antibody ipilimumab showed a consistent safety profile in special populations with advanced non-small cell lung cancer (NSCLC), according to...

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Non-Cystic Fibrosis Bronchiectasis: Which First-Line Antibiotic Is BEST for Kids?

(MedPage Today) -- Amoxicillin-clavulanate a good option, but questions remain about use in all kids Source link

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Cefuroxime, levofloxacin, esomeprazole, and bismuth as first-line therapy for eradicating Helicobacter pylori in patients allergic to penicillin

Eradicating Helicobacter pylori infection is clinically challenging, notably in cases with penicillin allergy. Cephalosporin could be used in lieu of amoxicillin to eradicate Helicobacter pylori. The current work... Source link

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Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial)

Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial) Source link

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Last Patient Enrolled in the Phase 2 Trial with Transgene’s TG4010 + Nivolumab + Chemotherapy for the First-Line Treatment of Advanced Lung Cancer (NSCLC)

STRASBOURG, France--(BUSINESS WIRE)--lt;a href="https://twitter.com/hashtag/TG4010?src=hash" target="_blank"gt;#TG4010lt;/agt;--Regulatory News: Transgene (Paris:TNG), a biotech company that designs and develops virus-based immunotherapies for the treatment of solid tumors, today announces that the last patient has...

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Simplifying switch to second line ART: Predicted effect of defining failure of first-line efavirenz-based regimens in sub-Saharan Africa by a single viral load > 1000 copies/ml

[ad_1] Shroufi, A; Van Cutsem, G; Cambiano, V; Bansi-Matharu, L; Duncan, K; Murphy, RA; Maman, D; Shroufi, A; Van Cutsem, G; Cambiano, V; Bansi-Matharu, L; Duncan, K; Murphy, RA; Maman,...

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Very high pre-therapy viral load is a predictor of virological rebound in HIV-1-infected patients starting a modern first-line regimen

[ad_1] Armenia, D; Di Carlo, D; Cozzi-Lepri, A; Calcagno, A; Borghi, V; Gori, C; Bertoli, A; ... ICONA Foundation Study Group, ; + view all Armenia, D; Di Carlo, D;...

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FDA Approves Ivosidenib as First-Line Therapy for AML

The agency reviewed the application for ivosidenib using its Real-Time Oncology Review pilot program. Source link

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Keytruda Gains 2 New First-Line Indications: NSCLC and RCC

The FDA approved pembrolizumab (Keytruda, Merck) for the first-line treatment of patients with stage III/IV non-small cell lung cancer who are not candidates for surgery or definitive chemoradiation. The agency...

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New First-Line Treatment for Severe Malaria in U.S.

[ad_1] Title: New First-Line Treatment for Severe Malaria in U.S.Category: Health NewsCreated: 3/28/2019 12:00:00 AMLast Editorial Review: 3/29/2019 12:00:00 AM Source link [ad_2]

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Anakinra as First-line Monotherapy Wins in sJIA (CME/CE)

(MedPage Today) -- Study reports "highly efficacious strategy to induce and sustain inactive disease and to prevent disease- and glucocorticoid-related damage" Source link

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KEYTRUDA® (pembrolizumab) in Combination with Inlyta® (axitinib) Reduced Risk of Death by Nearly Half Compared to Sunitinib as First-Line Treatment for Advanced Renal Cell Carcinoma (RCC)

[ad_1] KENILWORTH, N.J.--(BUSINESS WIRE)--lt;a href="https://twitter.com/search?q=%24MRK&src=ctag" target="_blank"gt;$MRKlt;/agt; lt;a href="https://twitter.com/hashtag/Keytruda?src=hash" target="_blank"gt;#Keytrudalt;/agt;--KEYTRUDA in Combination with Inlyta Reduced Risk of Death by Nearly Half Compared to Sunitinib as First-Line Treatment for Advanced RCC Source...

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No Benefit With Ramucirumab in First-Line Gastric Cancer Tx (CME/CE)

[ad_1] (MedPage Today) -- Unlike phase II results, no benefit seen in progression-free or overall survival Source link [ad_1]

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FDA Approves Imbruvica With Gazyva for First-Line CLL Treatment

[ad_1] The FDA expanded the labeling for Imbruvicato include use with Gazyva in treatment-naive patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.  Source link [ad_2]

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Treatment effects of the differential first-line antiretroviral regimens among HIV/HBV coinfected patients in southwest China: an observational study

[ad_1] Treatment effects of the differential first-line antiretroviral regimens among HIV/HBV coinfected patients in southwest China: an observational study Source link [ad_1]

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Tecentriq Combo Approved for First-Line Rx of Metastatic Nonsquamous NSCLC

[ad_1] The FDA approved atezolizumab (Tecentriq, Genentech) in combination with bevacizumab (Avastin, Genentech), paclitaxel and carboplatin for the first-line treatment of patients with metastatic nonsquamous, non-small cell lung cancer (NSCLC)...

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A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients

[ad_1] A two-microRNA-based signature predicts first-line chemotherapy outcomes in advanced colorectal cancer patients Source link [ad_1]

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Prostate cancer detection using MRI now first-line investigation tool

[ad_1] Men with prostate cancers under the NHS would soon get non-invasive MRI scans for detections after a health body (National Institute for Health and Care Excellence or NICE) has...

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New first-line treatment for peripheral T-cell lymphoma approved by FDA

[ad_1] The U.S. Food and Drug Administration today expanded the approved use of Adcetris (brentuximab vedotin) injection in combination with chemotherapy for adult patients with certain types of peripheral T-cell...

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Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART

[ad_1] Derache, A; Iwuji, CC; Danaviah, S; Giandhari, J; Marcelin, A-G; Calvez, V; de Oliveira, T; ... Gupta, RK; + view all Derache, A; Iwuji, CC; Danaviah, S; Giandhari, J;...

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