Tag : eukaryotic

Biology

Inverted translational control of eukaryotic gene expression by ribosome collisions

Newsemia
by Heungwon Park, Arvind R. Subramaniam The canonical model of eukaryotic translation posits that efficient translation initiation increases protein expression and mRNA stability. Contrary to...
Biology

Fission Yeast Asc1 Stabilizes the Interaction between Eukaryotic Initiation Factor 3a and Rps0A/uS2 for Protein Synthesis [Research Article]

Newsemia
Aminoacyl-tRNA synthetase cofactors play important roles in coordinating aminoacylation and translation. In this study, we describe an additional function of the fission yeast aminoacyl-tRNA synthetase...
Biology

Erratum for Sehrawat et al., "Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes" [Errata]

Newsemia
Erratum for Sehrawat et al., "Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes" [Errata]...
Biology

Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes [Research Article]

Newsemia
Protein synthesis is linked to cell proliferation, and its deregulation contributes to cancer. Eukaryotic translation initiation factor 1A (eIF1A) plays a key role in scanning...
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Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome

Newsemia
Goswami, P; Abid Ali, F; Douglas, ME; Locke, J; Purkiss, A; Janska, A; Eickhoff, P; … Costa, A; + view all Goswami, P; Abid Ali,...
Biology

EukRef: Phylogenetic curation of ribosomal RNA to enhance understanding of eukaryotic diversity and distribution

Newsemia
by Javier del Campo, Martin Kolisko, Vittorio Boscaro, Luciana F. Santoferrara, Serafim Nenarokov, Ramon Massana, Laure Guillou, Alastair Simpson, Cedric Berney, Colomban de Vargas, Matthew...
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding [Research Article]

Newsemia
The receptor for activated C kinase (RACK1), a conserved constituent of eukaryotic ribosomes, mediates phosphorylation of eukaryotic initiation factor 4G1(S1093) [eIF4G1(S1093)] and eIF3a(S1364) by protein...
Biology

Ribosomal RACK1:Protein Kinase C {beta}II Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation [Research Article]

Newsemia
Eukaryotic ribosomes contain the high-affinity protein kinase C βII (PKCβII) scaffold, receptor for activated C kinase (RACK1), but its role in protein synthesis control remains...
Biology

Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation [Research Article]

Newsemia
Translation initiation of most mRNAs involves m7G-cap binding, ribosomal scanning, and AUG selection. Initiation from an m7G-cap-proximal AUG can be bypassed resulting in leaky scanning,...
Biology

Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression.

Newsemia
Related Articles Influence of eukaryotic translation initiation factor 6 on non-small cell lung cancer development and progression. Eur J Cancer. 2018 Aug 01;101:165-180 Authors: Gantenbein...

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