Tag: Electron cryo-microscopy

Biology

Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae

Newsemia
by Manfeng Zhang, Huigang Shi, Xuemei Zhang, Xinzheng Zhang, Yihua Huang Curli play critical roles in biofilm formation, host cell adhesion, and colonization of inert...
Biology

Visualization of two architectures in class-II CAP-dependent transcription activation

Newsemia
by Wei Shi, Yanan Jiang, Yibin Deng, Zigang Dong, Bin Liu Transcription activation by cyclic AMP (cAMP) receptor protein (CAP) is the classic paradigm of...
Biology

Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures

Newsemia
by Hongxin Guan, Youwang Wang, Ting Yu, Yini Huang, Mianhuan Li, Abdullah F. U. H. Saeed, Vanja Perčulija, Daliang Li, Jia Xiao, Dongmei Wang, Ping...
Biology

Building de novo cryo-electron microscopy structures collaboratively with citizen scientists

Newsemia
by Firas Khatib, Ambroise Desfosses, Foldit Players , Brian Koepnick, Jeff Flatten, Zoran Popović, David Baker, Seth Cooper, Irina Gutsche, Scott Horowitz With the rapid...
Biology

A polymorphic helix of a Salmonella needle protein relays signals defining distinct steps in type III secretion

Newsemia
by Emily Z. Guo, Daniel C. Desrosiers, Jan Zalesak, James Tolchard, Mélanie Berbon, Birgit Habenstein, Thomas Marlovits, Antoine Loquet, Jorge E. Galán Type III protein-secretion...
Biology

Selection and characterization of ultrahigh potency designed ankyrin repeat protein inhibitors of <i>C</i>. <i>difficile</i> toxin B

Newsemia
by Rudo Simeon, Mengqiu Jiang, Ana M. Chamoun-Emanuelli, Hua Yu, Yongrong Zhang, Ran Meng, Zeyu Peng, Joanita Jakana, Junjie Zhang, Hanping Feng, Zhilei Chen Clostridium...
Biology

Structural basis for neutralization of hepatitis A virus informs a rational design of highly potent inhibitors

Newsemia
by Lei Cao, Pi Liu, Pan Yang, Qiang Gao, Hong Li, Yao Sun, Ling Zhu, Jianping Lin, Dan Su, Zihe Rao, Xiangxi Wang Hepatitis A...
Biology

Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains

Newsemia
by Hannah L. Turner, Jesper Pallesen, Shanshan Lang, Sandhya Bangaru, Sarah Urata, Sheng Li, Christopher A. Cottrell, Charles A. Bowman, James E. Crowe Jr., Ian...
Biology

Structure of the DP1–DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases

Newsemia
by Pierre Raia, Marta Carroni, Etienne Henry, Gérard Pehau-Arnaudet, Sébastien Brûlé, Pierre Béguin, Ghislaine Henneke, Erik Lindahl, Marc Delarue, Ludovic Sauguet PolD is an archaeal...

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