Tag : drugdrug

Pharma / Biotech

Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban.

Newsemia
Related Articles Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban. Eur J...
Pharma / Biotech

Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions.

Newsemia
Related Articles Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. Biopharm Drug Dispos. 2020 Jan 10;: Authors: Rytkönen J, Ranta VP, Kokki M, Kokki H,...
Pharma / Biotech

Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants.

Newsemia
Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants. J...
Pharma / Biotech

Potential drug-drug interactions associated with clinical and laboratory findings at hospital admission.

Newsemia
Related Articles Potential drug-drug interactions associated with clinical and laboratory findings at hospital admission. Int J Clin Pharm. 2019 Dec 21;: Authors: Kovačević M, Vezmar...
Pharma / Biotech

Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies.

Newsemia
Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies. J Pharm Sci. 2019 Nov 25;: Authors: Mitra A,...
Pharma / Biotech

Itraconazole increases ibrutinib exposure ten-fold and reduces inter-individual variation – A potentially beneficial drug-drug interaction.

Newsemia
Related Articles Itraconazole increases ibrutinib exposure ten-fold and reduces inter-individual variation – A potentially beneficial drug-drug interaction. Clin Transl Sci. 2019 Oct 30;: Authors: Tapaninen...
Pharma / Biotech

Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.

Newsemia
Related Articles Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects. J Clin Pharmacol. 2019 Sep 22;:...
Pharma / Biotech

CYP1A2 down-regulation by obeticholic acid: usefulness as a positive control for the in vitro evaluation of drug-drug interactions.

Newsemia
Related Articles CYP1A2 down-regulation by obeticholic acid: usefulness as a positive control for the in vitro evaluation of drug-drug interactions. J Pharm Sci. 2019 Aug...
Pharma / Biotech

Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy Adult Subjects.

Newsemia
Drug-Drug Interaction Study to Assess the Effect of Cytochrome P450 Inhibition and Induction on the Pharmacokinetics of the Novel Cereblon Modulator Avadomide (CC-122) in Healthy...
Pharma / Biotech

Population pharmacokinetics of dolutegravir: influence of drug-drug interactions in a real-life setting.

Newsemia
Related Articles Population pharmacokinetics of dolutegravir: influence of drug-drug interactions in a real-life setting. J Antimicrob Chemother. 2019 May 22;: Authors: Barcelo C, Aouri M,...
Pharma / Biotech

Studies of pharmacokinetics in beagle dogs and drug-drug interaction potential of a novel selective ZAK inhibitor 3h for hypertrophic cardiomyopathy treatment.

Newsemia
Related Articles Studies of pharmacokinetics in beagle dogs and drug-drug interaction potential of a novel selective ZAK inhibitor 3h for hypertrophic cardiomyopathy treatment. J Pharm...
Pharma / Biotech

Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers.

Newsemia
Related Articles Organic Anion Transporter Polypeptide 1B1 Polymorphism Modulates the Extent of Drug-Drug Interaction and Associated Biomarker Levels in Healthy Volunteers. Clin Transl Sci. 2019...
Pharma / Biotech

Drug-drug Interactions in Psychiatric Practice, Part 4: Classification of Neuropsychiatric Medications Based on Their Principal Mechanisms of Action (With Updated Neuroscience-based Nomenclature).

Newsemia
Related Articles Drug-drug Interactions in Psychiatric Practice, Part 4: Classification of Neuropsychiatric Medications Based on Their Principal Mechanisms of Action (With Updated Neuroscience-based Nomenclature). J...
Pharma / Biotech

Effects of prednisone on docetaxel pharmacokinetics in men with metastatic prostate cancer: A randomized drug-drug interaction study.

Newsemia
Related Articles Effects of prednisone on docetaxel pharmacokinetics in men with metastatic prostate cancer: A randomized drug-drug interaction study. Br J Clin Pharmacol. 2019 Feb...
AI/ML

Similarity-based machine learning support vector machine predictor of drug-drug interactions with improved accuracies.

Newsemia
Related Articles Similarity-based machine learning support vector machine predictor of drug-drug interactions with improved accuracies. J Clin Pharm Ther. 2018 Dec 18;: Authors: Song D,...
Pharma / Biotech

Semi-mechanistic population pharmacokinetic model to predict the drug-drug interaction between S-ketamine and ticlopidine in healthy human volunteers.

Newsemia
Semi-mechanistic population pharmacokinetic model to predict the drug-drug interaction between S-ketamine and ticlopidine in healthy human volunteers. CPT Pharmacometrics Syst Pharmacol. 2018 Aug 09;: Authors:...

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