Tag: drugdrug

Pharma / Biotech

Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug-Drug Interactions or in Special Populations: An Example Using Tofacitinib.

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Related Articles Application of Physiologically Based Pharmacokinetic Modeling to Predict Drug Exposure and Support Dosing Recommendations for Potential Drug-Drug Interactions or in Special Populations: An...
Pharma / Biotech

Understanding the Effect of Hydroxypropyl-β-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study.

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Related Articles Understanding the Effect of Hydroxypropyl-β-Cyclodextrin on Fenebrutinib Absorption in an Itraconazole-Fenebrutinib Drug-Drug Interaction Study. Clin Pharmacol Ther. 2020 Jun 14;: Authors: Durk MR,...
Pharma / Biotech

Absorption, Distribution, Metabolism, Excretion (ADME), Drug-drug interaction potential and Prediction of Human Pharmacokinetics of SUVN-G3031, a Novel Histamine 3 Receptor (H3R) inverse agonist in Clinical development for the treatment of Narcolepsy.

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Related Articles Absorption, Distribution, Metabolism, Excretion (ADME), Drug-drug interaction potential and Prediction of Human Pharmacokinetics of SUVN-G3031, a Novel Histamine 3 Receptor (H3R) inverse agonist...
Pharma / Biotech

Edoxaban and the Issue of Drug-Drug Interactions: From Pharmacology to Clinical Practice.

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Related Articles Edoxaban and the Issue of Drug-Drug Interactions: From Pharmacology to Clinical Practice. Drugs. 2020 Jun 05;: Authors: Corsini A, Ferri N, Proietti M,...
Pharma / Biotech

[Drug-drug Interactions in Intensive Care].

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[Drug-drug Interactions in Intensive Care]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2020 May;55(5):300-313 Authors: Drust A Abstract Drug-drug interactions are common problems in intensive care units. Numerous...
Pharma / Biotech

Pharmacologic treatment of transplant recipients infected with SARS-CoV-2: considerations regarding therapeutic drug monitoring and drug-drug interactions.

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Related Articles Pharmacologic treatment of transplant recipients infected with SARS-CoV-2: considerations regarding therapeutic drug monitoring and drug-drug interactions. Ther Drug Monit. 2020 Apr 15;: Authors:...
Pharma / Biotech

In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions.

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Related Articles In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions. Pharmacol Rep....
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Prediction of Clinical Transporter Mediated Drug‐Drug Interactions via Co‐measurement of Pitavastatin and Eltrombopag in Human Hepatocyte Models

Newsemia
Carter, SJ; Chouhan, B; Sharma, P; Chappell, MJ; (2020) Prediction of Clinical Transporter Mediated Drug‐Drug Interactions via Co‐measurement of Pitavastatin and Eltrombopag in Human Hepatocyte...
Pharma / Biotech

Safety and Pharmacokinetics of DS-1040 Drug-Drug Interactions With Aspirin, Clopidogrel, and Enoxaparin.

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Safety and Pharmacokinetics of DS-1040 Drug-Drug Interactions With Aspirin, Clopidogrel, and Enoxaparin. J Clin Pharmacol. 2020 Feb 27;: Authors: Limsakun T, Dishy V, Mendell J,...
Pharma / Biotech

Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban.

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Related Articles Value of quantifying ABC transporters by mass spectrometry and impact on in vitro-to-in vivo prediction of transporter-mediated drug-drug interactions of rivaroxaban. Eur J...
Pharma / Biotech

Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions.

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Related Articles Physiologically based pharmacokinetic modelling of oxycodone drug-drug interactions. Biopharm Drug Dispos. 2020 Jan 10;: Authors: Rytkönen J, Ranta VP, Kokki M, Kokki H,...
Pharma / Biotech

Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants.

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Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants. J...
Pharma / Biotech

Potential drug-drug interactions associated with clinical and laboratory findings at hospital admission.

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Related Articles Potential drug-drug interactions associated with clinical and laboratory findings at hospital admission. Int J Clin Pharm. 2019 Dec 21;: Authors: Kovačević M, Vezmar...
Pharma / Biotech

Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies.

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Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies. J Pharm Sci. 2019 Nov 25;: Authors: Mitra A,...
Pharma / Biotech

Itraconazole increases ibrutinib exposure ten-fold and reduces inter-individual variation – A potentially beneficial drug-drug interaction.

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Related Articles Itraconazole increases ibrutinib exposure ten-fold and reduces inter-individual variation – A potentially beneficial drug-drug interaction. Clin Transl Sci. 2019 Oct 30;: Authors: Tapaninen...
Pharma / Biotech

Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects.

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Related Articles Pharmacokinetic Drug-Drug Interactions Between Trospium Chloride and Ranitidine Substrates of Organic Cation Transporters in Healthy Human Subjects. J Clin Pharmacol. 2019 Sep 22;:...
Pharma / Biotech

CYP1A2 down-regulation by obeticholic acid: usefulness as a positive control for the in vitro evaluation of drug-drug interactions.

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Related Articles CYP1A2 down-regulation by obeticholic acid: usefulness as a positive control for the in vitro evaluation of drug-drug interactions. J Pharm Sci. 2019 Aug...

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