Tag : DNAbinding

AI/ML

DNAPred: Accurate Identification of DNA-Binding Sites from Protein Sequence by Ensembled Hyperplane-Distance-Based Support Vector Machines.

Newsemia
Related Articles DNAPred: Accurate Identification of DNA-Binding Sites from Protein Sequence by Ensembled Hyperplane-Distance-Based Support Vector Machines. J Chem Inf Model. 2019 06 24;59(6):3057-3071 Authors:...
Biology

A Krüppel-like factor 1 (KLF1) Mutation Associated with Severe Congenital Dyserythropoietic Anemia Alters Its DNA-Binding Specificity [Research Article]

Newsemia
Krüppel-like factor 1 (KLF1/EKLF) is a transcription factor that globally activates genes involved in erythroid cell development. Various mutations are identified in the human KLF1...
AI/ML

An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences.

Newsemia
Related Articles An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences. PLoS One. 2019;14(11):e0225317 Authors: Hu S,...
Biology

The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology [Research Article]

Newsemia
Fragments of the TAR DNA-binding protein 43 (TDP43) are major components of intracellular aggregates associated with amyotrophic lateral sclerosis and frontotemporal dementia. A variety of...
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A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal transducer and activator of transcription 3 (STAT3)

Newsemia
Shih, PC; Yang, Y; Parkinson, GN; Wilderspin, A; Wells, G; (2018) A high-throughput fluorescence polarization assay for discovering inhibitors targeting the DNA-binding domain of signal...
Biology

Complexes in aqueous cobalt(II)-2-picolinehydroxamic acid system: Formation equilibria, DNA-binding ability, antimicrobial and cytotoxic properties.

Newsemia
Related Articles Complexes in aqueous cobalt(II)-2-picolinehydroxamic acid system: Formation equilibria, DNA-binding ability, antimicrobial and cytotoxic properties. J Inorg Biochem. 2018 Jul 24;187:62-72 Authors: Woźniczka M,...

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