DNA damage

Researchers identify effective drug combinations for malignant brain tumor in mice

Usually, scientists study the molecular biology of cancer to find new treatments, but sometimes, it is the other way round: when trying to find new treatments, scientists find key information...

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Human body is a mosaic pattern of DNA mutations, say researchers

Researchers have discovered that the cells of the human body aren’t clones of a single DNA sequence, but are actually a mosaic of mutations. Source link

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Researchers identify new mechanism for accessing damaged DNA

UV light damages the DNA of skin cells, which can lead to skin cancer. Source link

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Viral study reveals new way to prevent kidney damage following organ transplant

While studying one of the smallest DNA viruses known, Sunnie Thompson, Ph.D., may have found a new way to help prevent kidney damage following organ transplant. Source link

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Yeast species thrives, despite losing DNA repair genes years ago

Researchers have discovered an ancient species of budding yeast that has lost dozens of DNA repair genes, without any adverse effects. Source link

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A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage

[ad_1] A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role...

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New research opens possibility of using sperm taken from testicles to overcome infertility

[ad_1] Scientists have found that sperm DNA from the testicles of many infertile men is as good as that of ejaculated sperm of fertile men. This may explain a major...

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Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

by Mingwei Min, Sabrina L. Spencer Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed to give rise to drug...

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Long noncoding RNAs: p53’s secret weapon in the fight against cancer?

[ad_1] by Emily Dangelmaier, Sarah B. Lazar, Ashish Lal p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor...

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Research sheds light on how motor enzyme can promote genome integrity

[ad_1] Approximately one per cent of each organism's genome encodes helicases. Helicases are mostly known as motor enzymes that can unwrap double-stranded DNA by use of energy. Source link [ad_2]

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Researchers uncover how the immune system protects from bowel cancer

[ad_1] Researchers from Charité - Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. Source link [ad_2]

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Sleep deprivation linked with DNA damage

[ad_1] Sleep deprivation was associated with DNA damage in a new Anesthesia study. In the observational study on 49 healthy full-time doctors who had their blood analyzed at different time...

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Novel biomarker links tumor progression to genome instability

[ad_1] Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in...

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Sperm health may play a role in recurrent miscarriages

[ad_1] The early-stage study, from scientists at Imperial College London, investigated the sperm quality of 50 men whose partners had suffered three or more consecutive miscarriages. Source link [ad_2]

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Scientists reveal how DNA damage leads to cancer and hereditary diseases

[ad_1] Scientists revealed how DNA damage influences mutations. Turned out that its contribution to mutagenesis was underestimated and many of the inheritance mutations are caused not by errors in DNA...

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Biological aging caused by cancer treatments correlates with cognitive decline

[ad_1] Cancer treatments are suspected to accelerate certain aging processes in the body. A new study has found that indicators of such biological aging correlate with declines in cognitive function...

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Failure of genetic repair system leads to chromosomal chaos

[ad_1] Scientists at the German Cancer Research Center have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known...

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Study offers new hope to patients with rare brain cancer

[ad_1] sGBM is a rare type of brain cancer in adults. The incidence varies from 2 to 5 per million people per year. For example, if Hong Kong's base population...

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Invasion of the P elements: Tolerance is not futile

[ad_1] by Colin D. Meiklejohn, Justin P. Blumenstiel Organisms are locked in an eternal struggle with parasitic DNA sequences that live inside their genomes and wreak havoc on their host’s...

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Loss of tumor protein p53 helps cancer cells grow in hostile environment

Researchers have discovered a novel consequence of loss of the tumor protein p53 that promotes cancer development, according to new findings in eLife. Source link

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