DNA damage
- February 14, 2019
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- Tags: cancerChromatinDNA damageDNA repairFightgene expressionGene RegulationlongLong non-coding RNAsNon-coding RNA sequencesnoncodingp53sRNAsSecretTumor suppressor genesWeapon
[ad_1] by Emily Dangelmaier, Sarah B. Lazar, Ashish Lal p53 regulates the expression of hundreds of genes. Recent surprising observations indicate that no single protein-coding gene controls the tumor suppressor...
Read more- February 11, 2019
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- Tags: Breast CancercancerDNADNA damageEnzymeGeneGenomehelicaseintegrityLightmotorPromoteresearchsheds
[ad_1] Approximately one per cent of each organism's genome encodes helicases. Helicases are mostly known as motor enzymes that can unwrap double-stranded DNA by use of energy. Source link [ad_2]
Read more- February 1, 2019
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- Tags: bacteriaBowelBowel CancercancerCellDNADNA damageimmuneImmune SystemimmunologyprotectsresearchResearcherssystemuncover
[ad_1] Researchers from Charité - Universitätsmedizin Berlin have discovered a protective mechanism which is used by the body to protect intestinal stem cells from turning cancerous. Source link [ad_2]
Read more- January 25, 2019
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- Tags: bloodDamagedeprivationDNADNA damageGenegene expressiongenesLinkedsleep
[ad_1] Sleep deprivation was associated with DNA damage in a new Anesthesia study. In the observational study on 49 healthy full-time doctors who had their blood analyzed at different time...
Read more- January 10, 2019
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- Tags: ataxiaAtaxia-TelangiectasiabiochemistryBiomarkercancerDNADNA damageGeneGeneticGenetic InformationgeneticsGenomeHospitalinstabilitylinksmedicinemoleculeprogressionproteinresearchTumor
[ad_1] Our DNA is under constant attack. The delicate molecule that contains our genetic information is extremely vulnerable to everything from environmental agents, such as radiation, to the chemicals in...
Read more- January 4, 2019
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- Tags: #healthbacteriaDNADNA damagemedicinemiscarriagemiscarriagesOXYGENplaypregnancyrecurrentresearchRoleSemenSperm
[ad_1] The early-stage study, from scientists at Imperial College London, investigated the sperm quality of 50 men whose partners had suffered three or more consecutive miscarriages. Source link [ad_2]
Read more- December 5, 2018
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- Tags: cancerCellCell DivisionDamagediseasesDNADNA damagegeneticsHereditaryLeadsmoleculeresearchrevealScientistsSperm
[ad_1] Scientists revealed how DNA damage influences mutations. Turned out that its contribution to mutagenesis was underestimated and many of the inheritance mutations are caused not by errors in DNA...
Read more- November 26, 2018
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- Tags: AgingbiologicalBreast Cancercancercancer treatmentCausedcognitiveCognitive FunctioncorrelatesDeclineDNADNA damageresearchtelomeraseTelomeretreatments
[ad_1] Cancer treatments are suspected to accelerate certain aging processes in the body. A new study has found that indicators of such biological aging correlate with declines in cognitive function...
Read more- November 12, 2018
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- Tags: braincancerCellchaoschromosomalchromosomeDNADNA damagedrugsFailureGeneticGenomeLeadsnucleusrepairresearchsystemTumor
[ad_1] Scientists at the German Cancer Research Center have now found a cause for the frequent catastrophic events in the genetic material of cancer cells that have only been known...
Read more- November 2, 2018
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- Tags: brainBrain CancercancerchemotherapyClinical TrialDNADNA damageevolutiongliomahopeHospitalLightmoleculeMutationNerveOfferspatientsRareRunningspinestudytemozolomideTumor
[ad_1] sGBM is a rare type of brain cancer in adults. The incidence varies from 2 to 5 per million people per year. For example, if Hong Kong's base population...
Read more- October 31, 2018
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- Tags: atrophyDNA damageDrosophila melanogasterElementsfutileinvasionInvertebrate genomicsParasite evolutionParasitic diseasesPlant genomicsToleranceTransposable elements
[ad_1] by Colin D. Meiklejohn, Justin P. Blumenstiel Organisms are locked in an eternal struggle with parasitic DNA sequences that live inside their genomes and wreak havoc on their host’s...
Read more- October 17, 2018
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- Tags: cancerCellCell DeathCellsDNADNA damageDNA replicationenvironmentGeneticGrowhelpshostilelossp53proteinresearchTumor
Researchers have discovered a novel consequence of loss of the tumor protein p53 that promotes cancer development, according to new findings in eLife. Source link
Read more- July 31, 2018
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- Tags: 039WearBiofortifiedCellCHORICropsDNADNA damageEatenlevelsmalnutritionreducesTear039Zinc
A new study by researchers from the UCSF Benioff Children's Hospital Oakland Research Institute (CHORI) shows that a modest 4 milligrams of extra zinc a day in the diet can...
Read more- July 28, 2018
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- Tags: braincancerclinical trialsDiffused Intrinsic Pontine GliomaDIPGDNA damageExperimental Treatmenthigh-grade gliomasMedulloblastomaMethodpediatricPediatric Brain Cancerpediatric neuro oncologypediatric neurologistPediatricsreportsresearchresearch fundingSmall MoleculeStoppingstudyUntreatable
Researchers used an experimental molecular therapy in preclinical laboratory tests to effectively treat several types of deadly pediatric brain cancer and now propose advancing the treatment to clinical testing in...
Read more- July 24, 2018
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- Tags: and rDNA instability is a potential driving force of genomic instability in cancer. In mammalsand recombination among repeats can lead to expansionsCellular senescence is a state of permanent cell cycle arrest that is induced by diverse types of stress associated with oncogene activationcontractionsDNA damageeven relatively low levels of senescent cells can have far-ranging effects that influence tissue function. In the human genomemaintaining rDNA stability is a serious challenge for genome integritymammalian rDNA genes are prone to instabilityor chromatin deregulation and can have tumor-suppressive effects. Howeveror translocations. Thusribosomal DNA (rDNA) genes comprise ∼350 copies distributed in large clusters. As in yeastsenescent cells also have profound deleterious effects that enhance tumor malignancy or contribute to tissue dysfunction in aging and disease. Indeedsenescent cells undergo dramatic alterations in metabolic and gene expression profiles with acquisition of a senescence-associated secretory phenotype (SASP). Through the SASPthere are seven sirtuins
As the research and development community devotes ever greater resources to the development of senolytic rejuvenation therapies based on selective destruction of senescent cells, further exploration of the biochemistry of...
Read more- July 24, 2018
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- Tags: AgingantagonizingapoptosiscontrolscytokinecytokinesDNA damageDrosophila melanogasterGastrointestinal tracthostImmunostainingRNA interferencesystemicvirusacquired
by Mohamed Mlih, Mobina Khericha, Christine Birdwell, A. Phillip West, Jason Karpac Aging is characterized by degeneration of unique tissues. However, dissecting the interconnectedness of tissue aging remains a challenge....
Read more- December 31, 1969
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- Tags: 12 samples (22.2%) of honey bees were found positive to insecticide presence out of 54 samples. The most frequently detected insecticide was chlorpyrifosa simple way to measure DNA strand breaks in eukaryotic cellsand acetamiprid were detected in seven samples of A. florea and five samples of A. dorsata. In totaland antioxidant enzyme activity were studied in Apis florea and A. dorsata honey bee samples collected from insecticide-treated and insecticide-free areas of PunjabchlorfenapyrdimethoateDNA damageemamectinimidaclopridInsecticide exposure can affect honey bees in agro-ecosystemsinsecticide incidencePakistan. Seven insecticides: chlorpyrifosphorateposing behavioral stresses that can lead to population decline. In this studywhich was found in four samples (7.4%)with a concentration ranging from 0.01 to 0.05 μg/g and an average concentration 0.03 μg/g. The comet assay or single cell gel electrophoresis assay
Related ArticlesInsecticide exposure affects DNA and antioxidant enzymes activity in honey bee species Apis florea and A. dorsata: Evidence from Punjab, Pakistan. Sci Total Environ. 2018 Sep 01;635:1292-1301 Authors: Hayat...
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