Researchers find direct link between MCL1 protein and cell-cycle checkpoint protein
Human cells respond to stresses like DNA damage, metabolic imbalance and starvation by first trying to repair the problem. Source link...
Tag : DNA damage
A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancers
by Kunming Zhao, Xingwen Wang, Xuting Xue, Li Li, Ying Hu Ataxia-telangiectasia mutated (ATM) is an apical kinase of the DNA damage response following DNA...
New repair mechanism for alcohol-induced DNA damage discovered
Researchers of the Hubrecht Institute in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way...
"Jumping genes" within eggs determine their survival
Females are born with a finite supply of eggs and with age the genetic quality of the eggs decline say researchers from Carnegie Institute. The...
Researchers confirm two new prognostic markers for triple negative breast cancer
Physicians who treat patients with triple negative breast cancer have two new ways to predict which patients may benefit most from the well-established post-surgery treatment...
New study uncovers multiple effects of little-known DNA repair protein
Injury and repair are part of the normal life cycle of any tissue or organ in the human body. However, if macroscopic tears or breaks...
Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation
by Cynthia J. Sakofsky, Natalie Saini, Leszek J. Klimczak, Kin Chan, Ewa P. Malc, Piotr A. Mieczkowski, Adam B. Burkholder, David Fargo, Dmitry A. Gordenin...
Blood sugar levels linked to DNA damage and cancer in diabetics
Increased blood sugar levels in diabetics could damage DNA and make the genome unstable, increasing the risk of certain cancers. Source link...
Researchers explain how diabetes increases cancer risk
For years, scientists have been trying to solve a medical mystery: Why do people with type 1 or type 2 diabetes have an increased risk...
Targeted pancreatic cancer drug shows promise in clinical trials
Researchers have conducted clinical trials with a new drug targeting pancreatic cancer and the initial results are promising. Source link...
New leukemia treatment developed from common wild flower
Researchers have discovered how to turn a compound from a common wildflower called Feverfew into a new treatment for leukemia. Source link...
Discovery of protective protein could open door to better treatment of fast-growing cancer cells
The discovery that an essential protein plays a protective role during cell division, could open the door to better targeted treatment of fast-growing cancer cells....
Mechanism Behind Low Cancer Occurrence In Bats Signals Potential Treatment Strategies For Humans
Cancer is a leading cause of death in aging populations. Despite decades of research, cancer treatments are still inefficient and have unacceptable side effects that...
Researchers identify effective drug combinations for malignant brain tumor in mice
Usually, scientists study the molecular biology of cancer to find new treatments, but sometimes, it is the other way round: when trying to find new...
Human body is a mosaic pattern of DNA mutations, say researchers
Researchers have discovered that the cells of the human body aren’t clones of a single DNA sequence, but are actually a mosaic of mutations. Source...
Researchers identify new mechanism for accessing damaged DNA
UV light damages the DNA of skin cells, which can lead to skin cancer. Source link...
Viral study reveals new way to prevent kidney damage following organ transplant
While studying one of the smallest DNA viruses known, Sunnie Thompson, Ph.D., may have found a new way to help prevent kidney damage following organ...
Yeast species thrives, despite losing DNA repair genes years ago
Researchers have discovered an ancient species of budding yeast that has lost dozens of DNA repair genes, without any adverse effects. Source link...
A gene regulatory multi-tool plays key role in unjamming the genome after DNA damage
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to...
New research opens possibility of using sperm taken from testicles to overcome infertility
Scientists have found that sperm DNA from the testicles of many infertile men is as good as that of ejaculated sperm of fertile men. This...