Tag : disposition

Pharma / Biotech

Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates.

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Related Articles Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates. Toxicol Appl Pharmacol....
Pharma / Biotech

Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities.

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Related Articles Investigation of MDR1-overexpressing cell lines to derive a quantitative prediction approach for brain disposition using in vitro efflux activities. Eur J Pharm Sci....
Pharma / Biotech

Predicting Paclitaxel Disposition in Humans with Whole-Body Physiologically-Based Pharmacokinetic Modeling.

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Related Articles Predicting Paclitaxel Disposition in Humans with Whole-Body Physiologically-Based Pharmacokinetic Modeling. CPT Pharmacometrics Syst Pharmacol. 2019 Oct 31;: Authors: Fu Q, Sun X, Lustburg...
Pharma / Biotech

Quantitative Proteomics and Mechanistic Modeling of Transporter-mediated Disposition in Non-Alcoholic Fatty Liver Disease.

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Related Articles Quantitative Proteomics and Mechanistic Modeling of Transporter-mediated Disposition in Non-Alcoholic Fatty Liver Disease. Clin Pharmacol Ther. 2019 Oct 20;: Authors: Vildhede A, Kimoto...
Pharma / Biotech

Inhibition of Carboxylesterase-1 Alters Clopidogrel Metabolism and Disposition.

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Related Articles Inhibition of Carboxylesterase-1 Alters Clopidogrel Metabolism and Disposition. Xenobiotica. 2019 Apr 30;:1-25 Authors: Laizure SC, Hu ZY, Potter PM, Parker RB Abstract 1....
Pharma / Biotech

Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model.

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Related Articles Methotrexate disposition, anti-folate activity and efficacy in the collagen-induced arthritis mouse model. Eur J Pharmacol. 2019 Apr 02;: Authors: Singh RK, van Haandel...
Pharma / Biotech

Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers.

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Related Articles Effects of proton pump inhibitors, esomeprazole and vonoprazan, on the disposition of proguanil, a CYP2C19 substrate, in healthy volunteers. Br J Clin Pharmacol....
Pharma / Biotech

Target-Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation and Optimal Dosing Strategy.

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Related Articles Target-Mediated Drug Disposition Model for Bispecific Antibodies: Properties, Approximation and Optimal Dosing Strategy. CPT Pharmacometrics Syst Pharmacol. 2018 Nov 27;: Authors: Schropp J,...
Pharma / Biotech

A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children.

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Related Articles A Population Pharmacokinetic Analysis to Study the Effect of Extracorporeal Membrane Oxygenation on Cefepime Disposition in Children. Pediatr Crit Care Med. 2018 Nov...
Pharma / Biotech

General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study.

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General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study. J Clin Pharmacol. 2018 Nov 02;: Authors: Bach T, Jiang Y,...
Pharma / Biotech

Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations.

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Related Articles Plasma and tissue disposition of danofloxacin in brown trout (Salmo trutta fario) after intravenous and intramuscular administrations. Food Addit Contam Part A Chem...
Pharma / Biotech

Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.

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Related Articles Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies. PLoS One. 2018;13(10):e0205435 Authors: Kratochwil NA, Dueker SR,...
Pharma / Biotech

Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study.

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Related Articles Influence of OCT1 ontogeny and genetic variation on morphine disposition in critically ill neonates: lessons from PBPK modeling and clinical study. Clin Pharmacol...

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