Tag : derivatives

Pharma / Biotech

Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α MAP Kinase Inhibitors.

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Related Articles Bioisosteric Replacement of Arylamide-Linked Spine Residues with N-Acylhydrazones and Selenophenes as a Design Strategy to Novel Dibenzosuberone Derivatives as Type I 1/2 p38α...
Pharma / Biotech

Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer's disease.

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Related Articles Synthesis and evaluation of 2-pyrrolopyridinylquinoline derivatives as selective tau PET tracers for the diagnosis of Alzheimer’s disease. Nucl Med Biol. 2020 Oct 26;93:11-18...
Cardiology

Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial.

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Related Articles Effect of ranolazine on plasma arginine derivatives and urinary isoprostane 8-iso-PGF2α in patients with myocardial infarction in the randomized RIMINI-Trial. Sci Rep. 2019...
Pharma / Biotech

Synthesis, oral bioavailability evaluation and antiplatelet aggregation activity of three derivatives of 3,4‑dihydroxyacetophenone.

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Related Articles Synthesis, oral bioavailability evaluation and antiplatelet aggregation activity of three derivatives of 3,4‑dihydroxyacetophenone. Int J Mol Med. 2020 Mar;45(3):919-930 Authors: Sun N, Qu...
Cardiology

Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives.

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Related Articles Pharmacological and cardiovascular perspectives on the treatment of COVID-19 with chloroquine derivatives. Acta Pharmacol Sin. 2020 Sep 23;: Authors: Zhang XL, Li ZM,...
Pharma / Biotech

Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators.

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Related Articles Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators. Bioorg Med Chem Lett. 2019 07 15;29(14):1785-1790 Authors: Tsuji T,...
Pharma / Biotech

Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors.

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Related Articles Design, Synthesis, and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel PI3K/mTOR Dual Inhibitors. J Med Chem. 2020 03 26;63(6):3028-3046 Authors: Yu Y, Han...
Pharma / Biotech

Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity.

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Related Articles Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity. Eur J...
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Synthesis and biological evaluation of some novel phosphate derivatives of the anti-viral drug araA

Newsemia
Shackleton, Janice Mary; (1993) Synthesis and biological evaluation of some novel phosphate derivatives of the anti-viral drug araA. Doctoral thesis (Ph.D), UCL (University College London)....
Pharma / Biotech

Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer's disease.

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Related Articles Design, synthesis and evaluation of pyrazole bearing α-aminophosphonate derivatives as potential acetylcholinesterase inhibitors against Alzheimer’s disease. Bioorg Chem. 2020 Jan 15;96:103589 Authors: Shaikh...
Pharma / Biotech

Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses.

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Related Articles Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses. Eur J Med Chem. 2019...
Pharma / Biotech

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands.

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Related Articles Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands. Bioorg Chem. 2019 Jun...
Pharma / Biotech

Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation.

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Related Articles Novel phenanthridin-6(5H)-one derivatives as potent and selective BET bromodomain inhibitors: Rational design, synthesis and biological evaluation. Eur J Med Chem. 2019 Jun 28;179:502-514...
Cardiology

Design and Development of Novel 1,3,5-Triazine-Procaine Derivatives as Protective Agent against Myocardial Ischemia/Reperfusion Injury via Inhibitor of Nuclear Factor-κB.

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Related Articles Design and Development of Novel 1,3,5-Triazine-Procaine Derivatives as Protective Agent against Myocardial Ischemia/Reperfusion Injury via Inhibitor of Nuclear Factor-κB. Pharmacology. 2019 Jun 18;:1-13...
Pharma / Biotech

Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability.

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Related Articles Studies on the interaction between HSA and new halogenated metformin derivatives: influence of lipophilic groups in the binding ability. J Biomol Struct Dyn....
Pharma / Biotech

Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors.

Newsemia
Synthesis and biological evaluation of 5-aminoethyl benzophenanthridone derivatives as DNA topoisomerase IB inhibitors. Eur J Med Chem. 2019 May 30;178:81-92 Authors: Tang WL, Zhang Y,...
Pharma / Biotech

New perspective on the metabolism of AD-1 in vivo: Characterization of a series of dammarane-type derivatives with novel metabolic sites and anticancer mechanisms of active oleanane-type metabolites.

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Related Articles New perspective on the metabolism of AD-1 in vivo: Characterization of a series of dammarane-type derivatives with novel metabolic sites and anticancer mechanisms...

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