Tag: Cell differentiation

Biology

Cell-based and multi-omics profiling reveals dynamic metabolic repurposing of mitochondria to drive developmental progression of <i>Trypanosoma brucei</i>

Newsemia
by Eva Doleželová, Michaela Kunzová, Mario Dejung, Michal Levin, Brian Panicucci, Clément Regnault, Christian J. Janzen, Michael P. Barrett, Falk Butter, Alena Zíková Mitochondrial metabolic...
Biology

A single-cell atlas of adult <i>Drosophila</i> ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis

Newsemia
by Allison Jevitt, Deeptiman Chatterjee, Gengqiang Xie, Xian-Feng Wang, Taylor Otwell, Yi-Chun Huang, Wu-Min Deng Oogenesis is a complex developmental process that involves spatiotemporally regulated...
Biology

Yap suppresses T-cell function and infiltration in the tumor microenvironment

Newsemia
by Eleni Stampouloglou, Nan Cheng, Anthony Federico, Emily Slaby, Stefano Monti, Gregory L. Szeto, Xaralabos Varelas A major challenge for cancer immunotherapy is sustaining T-cell...
Biology

High-throughput micropatterning platform reveals Nodal-dependent bisection of peri-gastrulation–associated versus preneurulation-associated fate patterning

Newsemia
by Mukul Tewary, Dominika Dziedzicka, Joel Ostblom, Laura Prochazka, Nika Shakiba, Tiam Heydari, Daniel Aguilar-Hidalgo, Curtis Woodford, Elia Piccinini, David Becerra-Alonso, Alice Vickers, Blaise Louis,...
Biology

Single-cell RNA sequencing reveals regulatory mechanism for trophoblast cell-fate divergence in human peri-implantation conceptuses

Newsemia
by Bo Lv, Qin An, Qiao Zeng, Xunyi Zhang, Ping Lu, Yanqiu Wang, Xianmin Zhu, Yazhong Ji, Guoping Fan, Zhigang Xue Multipotent trophoblasts undergo dynamic...
Biology

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids

Newsemia
by Sapna Chhabra, Lizhong Liu, Ryan Goh, Xiangyu Kong, Aryeh Warmflash During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers—endoderm, mesoderm and ectoderm,...
Biology

Control over single-cell distribution of G1 lengths by WNT governs pluripotency

Newsemia
by Jiwon Jang, Dasol Han, Mahdi Golkaram, Morgane Audouard, Guojing Liu, Daniel Bridges, Stefan Hellander, Alex Chialastri, Siddharth S. Dey, Linda R. Petzold, Kenneth S....
Biology

Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells

Newsemia
by Yiqin Ma, Daniel J. McKay, Laura Buttitta During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0...
Biology

Nessys: A new set of tools for the automated detection of nuclei within intact tissues and dense 3D cultures

Newsemia
by Guillaume Blin, Daina Sadurska, Rosa Portero Migueles, Naiming Chen, Julia A. Watson, Sally Lowell Methods for measuring the properties of individual cells within their...
Biology

LATS1/2 suppress NFκB and aberrant EMT initiation to permit pancreatic progenitor differentiation

Newsemia
by Caitlin M. Braitsch, D. Berfin Azizoglu, Yadanar Htike, Haley R. Barlow, Ulrike Schnell, Christopher P. Chaney, Thomas J. Carroll, Ben Z. Stanger, Ondine Cleaver...
Biology

Microstructural and functional gradients are increasingly dissociated in transmodal cortices

Newsemia
by Casey Paquola, Reinder Vos De Wael, Konrad Wagstyl, Richard A. I. Bethlehem, Seok-Jun Hong, Jakob Seidlitz, Edward T. Bullmore, Alan C. Evans, Bratislav Misic,...
Biology

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

Newsemia
by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis....
Biology

Time-dependent Pax3-mediated chromatin remodeling and cooperation with Six4 and Tead2 specify the skeletal myogenic lineage in developing mesoderm

Newsemia
by Alessandro Magli, June Baik, Lauren J. Mills, Il-Youp Kwak, Bridget S. Dillon, Ricardo Mondragon Gonzalez, David A. Stafford, Scott A. Swanson, Ron Stewart, James...
Biology

Developmental regulation of regenerative potential in <i>Drosophila</i> by ecdysone through a bistable loop of ZBTB transcription factors

Newsemia
by Karine Narbonne-Reveau, Cédric Maurange In many organisms, the regenerative capacity of tissues progressively decreases as development progresses. However, the developmental mechanisms that restrict regenerative...
Biology

Lens differentiation is controlled by the balance between PDGF and FGF signaling

Newsemia
by Hongge Li, Yingyu Mao, Michael Bouaziz, Honglian Yu, Xiuxia Qu, Fen Wang, Gen-Sheng Feng, Carrie Shawber, Xin Zhang How multiple receptor tyrosine kinases coordinate...
Biology

Insulin resistance disrupts epithelial repair and niche-progenitor Fgf signaling during chronic liver injury

Newsemia
by Fátima Manzano-Núñez, María José Arámbul-Anthony, Amparo Galán Albiñana, Aranzazu Leal Tassias, Carlos Acosta Umanzor, Irene Borreda Gascó, Antonio Herrera, Jerónimo Forteza Vila, Deborah J....
Biology

Long-distance communication: Looping of human papillomavirus genomes regulates expression of viral oncogenes

Newsemia
by Adityarup Chakravorty, Bill Sugden High-risk human papillomaviruses (HPVs) are a major cause of cancers. HPVs infect epithelial cells, and viral oncogenes disrupt several cellular...
Biology

Disruption of CTCF-YY1–dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription

Newsemia
by Ieisha Pentland, Karen Campos-León, Marius Cotic, Kelli-Jo Davies, C. David Wood, Ian J. Groves, Megan Burley, Nicholas Coleman, Joanne D. Stockton, Boris Noyvert, Andrew...
Biology

Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyte heterogeneity

Newsemia
by Valentina Cerrato, Elena Parmigiani, Maria Figueres-Oñate, Marion Betizeau, Jessica Aprato, Ishira Nanavaty, Paola Berchialla, Federico Luzzati, Claudio de’Sperati, Laura Lopez-Mascaraque, Annalisa Buffo The morphological,...

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