Tag: Cell cycle and cell division

Biology

Mitotic phosphorylation of the ULK complex regulates cell cycle progression

Newsemia
by Akinori Yamasaki, Yui Jin, Yoshinori Ohsumi Autophagy is an intracellular degradation pathway targeting organelles and macromolecules, thereby regulating various cellular functions. Phosphorylation is a...
Biology

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle

Newsemia
by Zhiyuan Li, Xiaofei Tian, Xinmiao Ji, Junjun Wang, Hanxiao Chen, Dongmei Wang, Xin Zhang Unc-51-like autophagy activating kinase 1 (ULK1)–autophagy-related 13 (ATG13) is the...
Biology

YTHDF2 promotes mitotic entry and is regulated by cell cycle mediators

Newsemia
by Qili Fei, Zhongyu Zou, Ian A. Roundtree, Hui-Lung Sun, Chuan He The N6-methyladenosine (m6A) modification regulates mRNA stability and translation. Here, we show that...
Biology

Eco-evolutionary significance of “loners”

Newsemia
by Fernando W. Rossine, Ricardo Martinez-Garcia, Allyson E. Sgro, Thomas Gregor, Corina E. Tarnita Loners—individuals out of sync with a coordinated majority—occur frequently in nature....
Biology

Evolutionary repair: Changes in multiple functional modules allow meiotic cohesin to support mitosis

Newsemia
by Yu-Ying Phoebe Hsieh, Vasso Makrantoni, Daniel Robertson, Adèle L. Marston, Andrew W. Murray The role of proteins often changes during evolution, but we do...
Biology

A conserved regulatory mechanism mediates the convergent evolution of plant shoot lateral organs

Newsemia
by Satoshi Naramoto, Victor Arnold Shivas Jones, Nicola Trozzi, Mayuko Sato, Kiminori Toyooka, Masaki Shimamura, Sakiko Ishida, Kazuhiko Nishitani, Kimitsune Ishizaki, Ryuichi Nishihama, Takayuki Kohchi,...
Biology

Transcription-induced formation of extrachromosomal DNA during yeast ageing

Newsemia
by Ryan M. Hull, Michelle King, Grazia Pizza, Felix Krueger, Xabier Vergara, Jonathan Houseley Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and...
Biology

Shaping of a three-dimensional carnivorous trap through modulation of a planar growth mechanism

Newsemia
by Karen J. I. Lee, Claire Bushell, Yohei Koide, John A. Fozard, Chunlan Piao, Man Yu, Jacob Newman, Christopher Whitewoods, Jerome Avondo, Richard Kennaway, Athanasius...
Biology

Changes in chromatin accessibility ensure robust cell cycle exit in terminally differentiated cells

Newsemia
by Yiqin Ma, Daniel J. McKay, Laura Buttitta During terminal differentiation, most cells exit the cell cycle and enter into a prolonged or permanent G0...
Biology

Nessys: A new set of tools for the automated detection of nuclei within intact tissues and dense 3D cultures

Newsemia
by Guillaume Blin, Daina Sadurska, Rosa Portero Migueles, Naiming Chen, Julia A. Watson, Sally Lowell Methods for measuring the properties of individual cells within their...
Biology

Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis

Newsemia
by Yuqiong Hu, Xiaoye Wang, Boqiang Hu, Yunuo Mao, Yidong Chen, Liying Yan, Jun Yong, Ji Dong, Yuan Wei, Wei Wang, Lu Wen, Jie Qiao,...
Biology

Simulations reveal challenges to artificial community selection and possible strategies for success

Newsemia
by Li Xie, Alex E. Yuan, Wenying Shou Multispecies microbial communities often display “community functions” arising from interactions of member species. Interactions are often difficult...
Biology

Cell aging preserves cellular immortality in the presence of lethal levels of damage

Newsemia
by Audrey Menegaz Proenca, Camilla Ulla Rang, Andrew Qiu, Chao Shi, Lin Chao Cellular aging, a progressive functional decline driven by damage accumulation, often culminates...
Biology

G1/S cell cycle regulators mediate effects of circadian dysregulation on tumor growth and provide targets for timed anticancer treatment

Newsemia
by Yool Lee, Nicholas F. Lahens, Shirley Zhang, Joseph Bedont, Jeffrey M. Field, Amita Sehgal Circadian disruption has multiple pathological consequences, but the underlying mechanisms...
Biology

HSP-4/BiP expression in secretory cells is regulated by a developmental program and not by the unfolded protein response

Newsemia
by Ji Zha, Mingjie Ying, Jasmine Alexander-Floyd, Tali Gidalevitz Differentiation of secretory cells leads to sharp increases in protein synthesis, challenging endoplasmic reticulum (ER) proteostasis....
Biology

Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

Newsemia
by Mingwei Min, Sabrina L. Spencer Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed...

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