Tag : Cell binding

Biology

Identification of N-linked glycans as specific mediators of neuronal uptake of acetylated α-Synuclein

Newsemia
by Melissa Birol, Slawomir P. Wojcik, Andrew D. Miranker, Elizabeth Rhoades Cell-to-cell transmission of toxic forms of α-Synuclein (αS) is thought to underlie disease progression...
Biology

The Cdk8/19-cyclin C transcription regulator functions in genome replication through metazoan Sld7

Newsemia
by Kerstin Köhler, Luis Sanchez-Pulido, Verena Höfer, Anika Marko, Chris P. Ponting, Ambrosius P. Snijders, Regina Feederle, Aloys Schepers, Dominik Boos Accurate genome duplication underlies...
Biology

CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity

Newsemia
by Branislav Ivan, Zhaozhi Sun, Harini Subbaraman, Nikolas Friedrich, Alexandra Trkola During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env)...
Biology

Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation

Newsemia
by Songhai Tian, Khaja Muneeruddin, Mei Yuk Choi, Liang Tao, Robiul H. Bhuiyan, Yuhsuke Ohmi, Keiko Furukawa, Koichi Furukawa, Sebastian Boland, Scott A. Shaffer, Rosalyn...
Biology

Transcriptional outcomes and kinetic patterning of gene expression in response to NF-κB activation

Newsemia
by Mingming Zhao, Jaimy Joy, Weiqiang Zhou, Supriyo De, William H. Wood III, Kevin G. Becker, Hongkai Ji, Ranjan Sen Transcription factor nuclear factor kappa...
Biology

CRISPR/Cas9 gene editing for the creation of an MGAT1-deficient CHO cell line to control HIV-1 vaccine glycosylation

Newsemia
by Gabriel Byrne, Sara M. O’Rourke, David L. Alexander, Bin Yu, Rachel C. Doran, Meredith Wright, Qiushi Chen, Parastoo Azadi, Phillip W. Berman Over the...

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