Tag : Bioavailability

Pharma / Biotech

Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.

Newsemia
Related Articles Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. Bioorg Med Chem Lett. 2019...
Pharma / Biotech

UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma.

Newsemia
Related Articles UHPLC-MS/MS method for pharmacokinetic and bioavailability determination of five bioactive components in raw and various processed products of Polygala tenuifolia in rat plasma....
Pharma / Biotech

Comparison of bioaccessibility and relative bioavailability of arsenic in rice bran: The in vitro with PBET/SHIME and in vivo with mice model.

Newsemia
Related Articles Comparison of bioaccessibility and relative bioavailability of arsenic in rice bran: The in vitro with PBET/SHIME and in vivo with mice model. Chemosphere. 2020 Nov;259:127443...
Pharma / Biotech

Mobility of trace metals in serpentinite-derived soils of the Pollino Massif (Southern Italy): insights on bioavailability and toxicity.

Newsemia
Related Articles Mobility of trace metals in serpentinite-derived soils of the Pollino Massif (Southern Italy): insights on bioavailability and toxicity. Environ Geochem Health. 2020 Jul;42(7):2215-2232...
Pharma / Biotech

Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC-MS/MS and Its Application in Pharmacokinetics and Bioavailability.

Newsemia
Related Articles Simultaneous Determination of Six Uncaria Alkaloids in Mouse Blood by UPLC-MS/MS and Its Application in Pharmacokinetics and Bioavailability. Biomed Res Int. 2020;2020:1030269 Authors:...
Pharma / Biotech

Rosuvastatin Lyophilized Tablets Loaded with Flexible Chitosomes for Improved Drug Bioavailability, Anti-hyperlipidemic and Anti-oxidant Activity.

Newsemia
Related Articles Rosuvastatin Lyophilized Tablets Loaded with Flexible Chitosomes for Improved Drug Bioavailability, Anti-hyperlipidemic and Anti-oxidant Activity. Int J Pharm. 2020 Aug 19;:119791 Authors: Ahmed...
Pharma / Biotech

Nanostructured Lipid Carriers for Oral Bioavailability Enhancement of Exemestane: Formulation Design, In Vitro, Ex Vivo, and In Vivo Studies.

Newsemia
Related Articles Nanostructured Lipid Carriers for Oral Bioavailability Enhancement of Exemestane: Formulation Design, In Vitro, Ex Vivo, and In Vivo Studies. J Pharm Sci. 2019 10;108(10):3382-3395 Authors: Singh...
Pharma / Biotech

Dual Formulation and Interaction Strategies to Enhance the Oral Bioavailability of Paclitaxel.

Newsemia
Dual Formulation and Interaction Strategies to Enhance the Oral Bioavailability of Paclitaxel. J Pharm Sci. 2020 Jul 31;: Authors: Al-Kandari BM, Al-Soraj MH, Hedaya MA...
Pharma / Biotech

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability.

Newsemia
Related Articles Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability. Eur J Med Chem. 2020 Jul...
Pharma / Biotech

The bioavailability and maturing clearance of doxapram in preterm infants.

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Related Articles The bioavailability and maturing clearance of doxapram in preterm infants. Pediatr Res. 2020 Jul 22;: Authors: Flint RB, Simons SHP, Andriessen P, Liem...
Pharma / Biotech

Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility.

Newsemia
Related Articles Biopharmaceutics and Pharmacokinetics of Timosaponin A-III by a Sensitive HPLC-MS/MS Method: Low Bioavailability Resulting from Poor Permeability and Solubility. Curr Pharm Biotechnol. 2020...
Pharma / Biotech

First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects.

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Related Articles First-in-human, phase I single-ascending-dose study of the safety, pharmacokinetics, and relative bioavailability of selatinib, a dual EGFR-ErbB2 inhibitor in healthy subjects. Invest New...
Pharma / Biotech

Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats.

Newsemia
Related Articles Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats. J Pharm Biomed Anal. 2020 May 25;188:113376 Authors: Fan Y,...
Pharma / Biotech

Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry.

Newsemia
Enhancing the oral bioavailability of simvastatin with silica-lipid hybrid particles: The effect of supersaturation and silica geometry. Eur J Pharm Sci. 2020 May 20;150:105357 Authors:...
Pharma / Biotech

A descriptive bibliometric study on bioavailability of pesticides in vegetables, food or wine research (1976-2018).

Newsemia
Related Articles A descriptive bibliometric study on bioavailability of pesticides in vegetables, food or wine research (1976-2018). Environ Toxicol Pharmacol. 2020 Mar 20;77:103374 Authors: Andreo-Martínez...
Pharma / Biotech

Intra- and Interlaboratory Evaluation of an Assay of Soil Arsenic Relative Bioavailability in Mice.

Newsemia
Related Articles Intra- and Interlaboratory Evaluation of an Assay of Soil Arsenic Relative Bioavailability in Mice. J Agric Food Chem. 2020 Mar 04;68(9):2615-2622 Authors: Bradham...

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