Tag: binding

Latest News

Avidity of binding responsible for cross-neutralization of SARS-CoV-1 and SARS-CoV-2

Newsemia
In a new study published on the preprint server bioRxiv researchers characterized the crystal structure of the antibody-SARS-CoV-2 RBD complex in an attempt to find...
Latest News

Design and Synthesis of G-Quadruplex Binding Small Molecules and their Evaluation as Anti-Cancer Agents

Newsemia
Hampel, Sonja Margarethe; (2011) Design and Synthesis of G-Quadruplex Binding Small Molecules and their Evaluation as Anti-Cancer Agents. Doctoral thesis (Ph.D), UCL (University College London)....
Biology

Human Insulin Growth Factor 2 mRNA Binding Protein 2 Increases MicroRNA 33a/b Inhibition of Liver ABCA1 Expression and Alters Low-Density Apolipoprotein Levels in Mice [Research Article]

Newsemia
Genome-wide association studies (GWAS) have linked IGF2BP2 single-nucleotide polymorphisms (SNPs) with type 2 diabetes (T2D). Mice overexpressing mIGF2BP2 have elevated cholesterol levels when fed a...
Latest News

Synthesis and DNA binding properties of peptides based on the bZip motif

Newsemia
Sheady, Sarah Elizabeth; (2000) Synthesis and DNA binding properties of peptides based on the bZip motif. Doctoral thesis (Ph.D), UCL (University College London). Green open...
Pharma / Biotech

Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study.

Newsemia
Related Articles Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical...
Cardiology

Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation.

Newsemia
Related Articles Cold-inducible RNA binding protein agonist enhances the cardioprotective effect of UW solution during extended heart preservation. Artif Organs. 2020 Apr 12;: Authors: Pan...
Biology

Unraveling the Hierarchy of cis and trans Factors That Determine the DNA Binding by Peroxisome Proliferator-Activated Receptor {gamma} [Research Article]

Newsemia
Peroxisome proliferator-activated receptor (PPAR) is a nuclear receptor essential for adipocyte development and the maintenance of the alternatively polarized macrophage phenotype. Biochemical studies have established...
Biology

Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy

Newsemia
by Linxiang Yin, Geoffrey Masuyer, Sicai Zhang, Jie Zhang, Shin-Ichiro Miyashita, David Burgin, Laura Lovelock, Shu-Fen Coker, Tian-min Fu, Pål Stenmark, Min Dong Botulinum neurotoxins...
AI/ML

Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease.

Newsemia
Related Articles Characterizing Protein-Ligand Binding Using Atomistic Simulation and Machine Learning: Application to Drug Resistance in HIV-1 Protease. J Chem Theory Comput. 2020 Feb 11;16(2):1284-1299...
AI/ML

Predicting the impacts of mutations on protein-ligand binding affinity based on molecular dynamics simulations and machine learning methods.

Newsemia
Related Articles Predicting the impacts of mutations on protein-ligand binding affinity based on molecular dynamics simulations and machine learning methods. Comput Struct Biotechnol J. 2020;18:439-454...
Biology

Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca<sup>2+</sup>, and receptor binding

Newsemia
by Dibyendu Kumar Das, Uriel Bulow, William E. Diehl, Natasha D. Durham, Fernando Senjobe, Kartik Chandran, Jeremy Luban, James B. Munro The Ebola virus (EBOV)...
Pharma / Biotech

Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants.

Newsemia
Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants. J...

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