apoptosis
- November 29, 2019
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- Tags: 5fluorouracilapoptosisautophagiccancerCellColorectaldeathIncreasesInducingPCDH17sensitivitytreatment
PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death Source link
Read more- November 28, 2019
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- Tags: apoptosisCardiomyocyteCaSRCaSR;MCP-1/CCL2;MCPIP1;apoptosis;ischemia/reperfusionIschemiaReperfusionInducedMCP1MCPIP1mediates
Related Articles MCP-1 mediates ischemia/reperfusion-induced cardiomyocyte apoptosis via MCPIP1 and CaSR. Am J Physiol Heart Circ Physiol. 2019 Nov 27;: Authors: Zhang W, Zhu T, Chen L, Luo W, Chao...
Read more- November 23, 2019
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- Tags: antineoplasticityapoptosisApoptosis;Breast Cancer;Centchroman;Genistein;Ormeloxifene;PI3K/AktbreastcancerCentchromandeactivationdependentGenisteininducedinductionPI3KAktpotentiatesROS
Related Articles Genistein potentiates Centchroman induced antineoplasticity in breast cancer via PI3K/Akt deactivation and ROS dependent induction of apoptosis. Life Sci. 2019 Nov 18;:117073 Authors: Kaushik S, Shyam H, Agarwal...
Read more- November 19, 2019
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- Tags: apoptosisbrainBrain TumorcancerCellCell DeathDecideDiesfactorsGlioblastomagrowsligandproteinReceptorresearchstudyTumor
A new study published today in the journal Cell Reports by scientists at the German Cancer Research Center (DKFZ) shows that the direction taken by a cancer cell depends on...
Read more- November 16, 2019
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- Tags: apoptosisAutophagyBacillustreatedCellsDermalDHTdihydrotestosteronetreatedextractfruithumanIsolatedjaponicamediatesMtorc1PapillapeptiderescuessignalingSuppressionTrapa
The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression Source link
Read more- November 15, 2019
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- Tags: Animals;Apoptosis;Autophagy;Carps;Chlorpyrifos;Gene Expression Regulation;Gene Ontology;Head Kidney;MicroRNAs;RNAapoptosiscarpchemicalChlorpyrifoscommoninducedinjurykidneyMediatingMessenger;Reproducibility of Results;Toll-Like Receptors;Water PollutantsmiR21883pmiR731PathwaysRoleTargetingTLR
Related Articles Role of miR-731 and miR-2188-3p in mediating chlorpyrifos induced head kidney injury in common carp via targeting TLR and apoptosis pathways. Aquat Toxicol. 2019 Oct;215:105286 Authors: Liu Q,...
Read more- November 11, 2019
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- Tags: apoptosiscancerColorectalFeedbacklimitsloopMYCdependentMYCGCN2eIF2αnegativepreventproteinsynthesis
A MYC–GCN2–eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer Source link
Read more- November 7, 2019
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- Tags: apoptosiscancercannabidiolgastricpromotesregulationXIAPSmac
Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer Source link
Read more- October 29, 2019
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- Tags: activationapoptosisApoptosis;Artemisinin;Bone marrow mesenchymal stem cells;CREB;Erk1/2;Phosphorylation;Protection;ROS;Raf;p90rskartemisininboneCellscRafErk12p90rskCREBhydrogeninducedmarrowderivedMechanismmesenchymalpathwayperoxideProtectiveratstem
Related Articles Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway. Stem Cell Res Ther. 2019 Oct...
Read more- October 19, 2019
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- Tags: apoptosisCellsDeletion mutationDNA repairDNA replicationEarlyembryonicEmbryosGenomichumanInducinginstabilityKHDC3LlossMammalian genomicsMutationPhosphorylationpregnancyrecurrent
by Weidao Zhang, Zhongliang Chen, Dengfeng Zhang, Bo Zhao, Lu Liu, Zhengyuan Xie, Yonggang Yao, Ping Zheng Recurrent pregnancy loss (RPL) is an important complication in reproductive health. About 50%...
Read more- October 18, 2019
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- Tags: apoptosisAstrocytesdeathdevelopmentDiphtheriaimplementedLargeScalemicrogliaMicroglial cellsnonapoptoticnormalPHAGOCYTESRetinaretinalretinal ganglion cellsToxins
by Vanessa M. Puñal, Caitlin E. Paisley, Federica S. Brecha, Monica A. Lee, Robin M. Perelli, Jingjing Wang, Emily G. O’Koren, Caroline R. Ackley, Daniel R. Saban, Benjamin E. Reese,...
Read more- October 1, 2019
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- Tags: apoptosisCalreticulinCellCell DeathCell stainingChaperone proteinsCriticalfactorFluorescence-activated cell sortingMalignantMelanoma CellsMitochondrianeoplasmsRNA stem-loop structuresurvival
by Arum Han, Chen Li, Tara Zahed, Michael Wong, Ian Smith, Karl Hoedel, Douglas Green, Alexander D. Boiko Calreticulin (CRT) is a high-capacity Ca2+ protein whose expression is up-regulated during...
Read more- September 13, 2019
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- Tags: activityapoptosisAtherogenicattenuatebloodcardiovascular diseasecholesterolfastingGLUCOSEMenopausalMenopausemusclephysicalphysical activityresearchtriglycerideunfavorablewomen
A new study on menopausal women shows that leisure-time physical activity is associated with a healthier blood lipid profile. However, results suggest that leisure-time physical activity does not seem to...
Read more- September 4, 2019
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- Tags: activatingapoptosisbaicalinCellH9c2HIF1αBNIP3hypoxiaarousedMyocardial ischemia;Nrf2/HO-1 pathway;baicalin;cardiomyocytes damage;hypoxia;hypoxia-inducible factor 1αNrf2HO1mediatedpathwayRelieves
Related Articles Baicalin relieves hypoxia-aroused H9c2 cell apoptosis by activating Nrf2/HO-1-mediated HIF1α/BNIP3 pathway. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3657-3663 Authors: Yu H, Chen B, Ren Q Abstract Background: Myocardial ischemia...
Read more- August 29, 2019
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- Tags: apoptosiscalciumcancerCellCell DeathCellsDescribeInducesIntracellularIonKAISTMechanismOXYGENpotassiumProgrammed Cell DeathresearchResearchersselfkillingstressTumor
Researchers have described a new mechanism which induces the self-killing of cancer cells by perturbing ion homeostasis. A research team from the Department of Biochemical Engineering has developed helical polypeptide...
Read more- August 18, 2019
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- Tags: apoptosisBRAFV600EinducedcancerCellschemotherapyinducedcolonhumanIntrinsicPDL1regulateTumorXenografts
BRAFV600E-induced, tumor intrinsic PD-L1 can regulate chemotherapy-induced apoptosis in human colon cancer cells and in tumor xenografts Source link
Read more- August 9, 2019
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- Tags: apoptosisAutophagycancerCellschaperonemediateddownregulationEndoplasmicInducesOptineurinPancreaticReticulumstress
Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells Source link
Read more- August 9, 2019
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- Tags: apoptosisCaspasedownregulationepithelialExpressioninflammationinducedlimitsOccludinsuppressing
Epithelial tight junctions are compromised in patients with gastrointestinal disease. Occludin is a protein component of tight junctions; its removal from tight junctions or reduced expression results in barrier loss....
Read more- August 9, 2019
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- Tags: ABT263apoptosisBCL2BCLXLCDK7cholangiocarcinomacombinationdrivesInhibitorInhibitsMCL1synthesisTHZ1
CDK7 inhibitor THZ1 inhibits MCL1 synthesis and drives cholangiocarcinoma apoptosis in combination with BCL2/BCL-XL inhibitor ABT-263 Source link
Read more- July 21, 2019
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- Tags: accumulatedAKTAkt;Apoptosis;Autophagic flux;Autophagosome;MaduramicinapoptosisautophagicautophagosomesdependentCellsFluximpairsinactivationLeadingMaduramicinmyoblastskeletal
Maduramicin inactivation of Akt impairs autophagic flux leading to accumulated autophagosomes-dependent apoptosis in skeletal myoblast cells. Int J Biochem Cell Biol. 2019 Jul 17;:105573 Authors: Dong X, Zhao R, Li...
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