Tag : Antisense

Latest News

Inhibition of SARS-CoV-2 with antisense oligonucleotides

Newsemia
A part of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral RNA is highly conserved. Researchers have used this as a target for designing...
Dermatology

QR-313, an antisense oligonucleotide, shows therapeutic efficacy for treatment of dominant and recessive dystrophic epidermolysis bullosa: a preclinical study

Newsemia
Dystrophic epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in the gene COL7A1 encoding collagen VII. DEB can be inherited in a...
Pharma / Biotech

Approaches for Systemic Delivery of Dystrophin Antisense Peptide Nucleic Acid in the mdx Mouse Model.

Newsemia
Approaches for Systemic Delivery of Dystrophin Antisense Peptide Nucleic Acid in the mdx Mouse Model. Nucleic Acid Ther. 2020 Jul 15;: Authors: Brolin C, Lim...
Gastroenterology

Novel antisense drug shows promise to improve health of people with NAFLD

Newsemia
Using a first-of-its-class drug in a clinical trial, an international research effort headed by a scientist at University of California San Diego School of Medicine...
Neurology

New breakthrough offers hope for potential treatment of rare childhood epilepsy

Newsemia
Seizure disorders in babies are frightening and heartbreaking. A new basic science breakthrough offers hope for a potential treatment for rare developmental and epileptic encephalopathies...
Latest News

RNA-Seq Analysis of an Antisense Sequence Optimized for Exon Skipping in Duchenne Patients Reveals No Off-Target Effect

Newsemia
Domenger, C; Allais, M; François, V; Léger, A; Lecomte, E; Montus, M; Servais, L; … Le Guiner, C; + view all Domenger, C; Allais, M;...
Latest News

Targeting Cx26 Expression by Sustained Release of Cx26 Antisense from Scaffolds Reduces Inflammation and Improves Wound Healing

Newsemia
Phillips, ARJ; Chin, JS; Madden, L; Gilmartin, DJ; Soon, A; Thrasivoulou, C; Jayasinghe, SN; … Becker, DL; + view all Phillips, ARJ; Chin, JS; Madden,...
Gastroenterology

Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma

Newsemia
Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma Source link...
Pharma / Biotech

Targeting Listeria monocytogenes consensus sequence of internalin genes using an antisense molecule.

Newsemia
Related Articles Targeting Listeria monocytogenes consensus sequence of internalin genes using an antisense molecule. Microb Pathog. 2019 Aug 21;:103689 Authors: Kalani BS, Najafi M, Mohammadzadeh...
Pharma / Biotech

The Pharmacokinetics of 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy.

Newsemia
Related Articles The Pharmacokinetics of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2019 Aug 20;:...
Latest News

New drug provides hope for patients with Duchenne muscular dystrophy

Newsemia
The results from three clinical trials have shown that a new drug can successfully delay the progression of Duchenne muscular dystrophy. Source link...

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