Tag : Antisense

Neurology

New breakthrough offers hope for potential treatment of rare childhood epilepsy

Newsemia
Seizure disorders in babies are frightening and heartbreaking. A new basic science breakthrough offers hope for a potential treatment for rare developmental and epileptic encephalopathies...
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RNA-Seq Analysis of an Antisense Sequence Optimized for Exon Skipping in Duchenne Patients Reveals No Off-Target Effect

Newsemia
Domenger, C; Allais, M; François, V; Léger, A; Lecomte, E; Montus, M; Servais, L; … Le Guiner, C; + view all Domenger, C; Allais, M;...
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Targeting Cx26 Expression by Sustained Release of Cx26 Antisense from Scaffolds Reduces Inflammation and Improves Wound Healing

Newsemia
Phillips, ARJ; Chin, JS; Madden, L; Gilmartin, DJ; Soon, A; Thrasivoulou, C; Jayasinghe, SN; … Becker, DL; + view all Phillips, ARJ; Chin, JS; Madden,...
Gastroenterology

Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma

Newsemia
Aberrant hypermethylation-mediated downregulation of antisense lncRNA ZNF667-AS1 and its sense gene ZNF667 correlate with progression and prognosis of esophageal squamous cell carcinoma Source link...
Pharma / Biotech

Targeting Listeria monocytogenes consensus sequence of internalin genes using an antisense molecule.

Newsemia
Related Articles Targeting Listeria monocytogenes consensus sequence of internalin genes using an antisense molecule. Microb Pathog. 2019 Aug 21;:103689 Authors: Kalani BS, Najafi M, Mohammadzadeh...
Pharma / Biotech

The Pharmacokinetics of 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy.

Newsemia
Related Articles The Pharmacokinetics of 2′-O-Methyl Phosphorothioate Antisense Oligonucleotides: Experiences from Developing Exon Skipping Therapies for Duchenne Muscular Dystrophy. Nucleic Acid Ther. 2019 Aug 20;:...
Latest News

New drug provides hope for patients with Duchenne muscular dystrophy

Newsemia
The results from three clinical trials have shown that a new drug can successfully delay the progression of Duchenne muscular dystrophy. Source link...
Biology

Expression of Concern for Lee et al., "Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression" [Expression Of Concern]

Newsemia
Expression of Concern for Lee et al., "Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense...
Neurology

New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

Newsemia
A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing...
Neurology

NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy.

Newsemia
NS-065/NCNP-01: An Antisense Oligonucleotide for Potential Treatment of Exon 53 Skipping in Duchenne Muscular Dystrophy. Mol Ther Nucleic Acids. 2018 Sep 27;13:442-449 Authors: Watanabe N,...

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