Tag : angiotensin

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SARS-CoV-2 spike protein shows slow but stable evolution, study finds

Newsemia
A new preprint published in November 2020 describes the seven different clades into which the virus has diversified. Source link...
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Monoclonal antibody HB27 shows potent neutralizing activity against SARS-CoV-2

Newsemia
A new study reports a very promising anti-SARS-CoV-2 monoclonal antibody, HB27, that appears to have two distinct mechanisms of action inhibiting the virus-host cell interaction...
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N439K mutation of SARS-CoV-2 may be more infectious and antibody resistant than Wuhan strain

Newsemia
Researchers from the Harbin Institute of Technology, China, modeled the complexes formed between the RBD and the human ACE2 and monoclonal antibodies. Source link...
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Novel cannabis plant extracts could protect against COVID-19

Newsemia
Researchers in Canada have conducted a study suggesting that novel Cannabis sativa extracts may decrease levels of the host cell receptor that severe acute respiratory...
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Early interferon therapy may mitigate COVID-19 severity

Newsemia
A recent review of COVID-19 therapies explores the utility of interferons in the battle against severe COVID-19, and concludes that they deserve further development. Source...
Cardiology

Sacubitril/Valsartan Inhibits Cardiomyocyte Hypertrophy in Angiotensin II-Induced Hypertensive Mice Independent of a Blood Pressure-Lowering Effect.

Newsemia
Related Articles Sacubitril/Valsartan Inhibits Cardiomyocyte Hypertrophy in Angiotensin II-Induced Hypertensive Mice Independent of a Blood Pressure-Lowering Effect. Cardiol Res. 2020 Dec;11(6):376-385 Authors: Tashiro K, Kuwano...
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Scientists show SARS-CoV-2's viral replication with 3D integrative imaging

Newsemia
A team of researchers at Heidelberg University in Germany have performed a detailed imaging analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to...
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SARS-CoV-2's spike protein mutations have slowed, study finds

Newsemia
A team of researchers at the School of Information Sciences in Illinois, USA, has revealed the rate of mutation in the 29 proteins that make...
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Modified SARS-CoV-2 receptor-binding domain could increase vaccine efficacy, says study

Newsemia
A team of researchers from the USA and China have engineered a receptor-binding domain (RBD) that they claim improves the immunogenicity of multivalent SARS-CoV-2 vaccines....
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Compounds in traditional Chinese medicine herbs may inhibit SARS-CoV-2 infection

Newsemia
Using computational methods, a team of researchers identified three compounds in traditional Chinese medicine that could be used against SARS-CoV-2. Source link...
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SARS-CoV-2 suppresses ACE2 activity in COVID-19 patients

Newsemia
A recent study conducted by a team of international scientists has revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus...
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Around 10 SARS-CoV-2 virions per cell in human body, study finds

Newsemia
A new study has found that there are about ten virus particles in each cell in the body. The research team from the Weizmann Institute...
Pharma / Biotech

Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure.

Newsemia
Related Articles Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure. Acta Ophthalmol. 2020 Nov 16;: Authors: Lorenzo-Soler...
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Identifying SARS-CoV-2 spike protein mutations resistant to antibodies

Newsemia
Using a set of different monoclonal antibodies, researchers determined different mutations in the SARS-CoV-2 spike protein that leads to resistance. Understanding these resistant mutations is...
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Immune-evading variants can emerge in SARS-CoV-2, researchers warn

Newsemia
An international team of researchers has shown that a mutation within severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus...
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5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Newsemia
Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is...
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ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

Newsemia
A recent study published on the preprint server bioRxiv in October 2020 shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding to the human...
Cardiology

A Retrospective Study from 2 Centers in China on the Effects of Continued Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers in Patients with Hypertension and COVID-19.

Newsemia
Related Articles A Retrospective Study from 2 Centers in China on the Effects of Continued Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers...
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Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

Newsemia
Researchers at Tsinghua University, Beijing, have conducted a study providing possible new insights into the evolution and cross-species transmission of severe acute respiratory syndrome coronavirus...

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