Tag : Angiotensin-Converting Enzyme 2

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SARS-CoV-2 spike protein shows slow but stable evolution, study finds

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A new preprint published in November 2020 describes the seven different clades into which the virus has diversified. Source link...
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Monoclonal antibody HB27 shows potent neutralizing activity against SARS-CoV-2

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A new study reports a very promising anti-SARS-CoV-2 monoclonal antibody, HB27, that appears to have two distinct mechanisms of action inhibiting the virus-host cell interaction...
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N439K mutation of SARS-CoV-2 may be more infectious and antibody resistant than Wuhan strain

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Researchers from the Harbin Institute of Technology, China, modeled the complexes formed between the RBD and the human ACE2 and monoclonal antibodies. Source link...
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Novel cannabis plant extracts could protect against COVID-19

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Researchers in Canada have conducted a study suggesting that novel Cannabis sativa extracts may decrease levels of the host cell receptor that severe acute respiratory...
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Early interferon therapy may mitigate COVID-19 severity

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A recent review of COVID-19 therapies explores the utility of interferons in the battle against severe COVID-19, and concludes that they deserve further development. Source...
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Scientists show SARS-CoV-2's viral replication with 3D integrative imaging

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A team of researchers at Heidelberg University in Germany have performed a detailed imaging analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection to...
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SARS-CoV-2's spike protein mutations have slowed, study finds

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A team of researchers at the School of Information Sciences in Illinois, USA, has revealed the rate of mutation in the 29 proteins that make...
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Modified SARS-CoV-2 receptor-binding domain could increase vaccine efficacy, says study

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A team of researchers from the USA and China have engineered a receptor-binding domain (RBD) that they claim improves the immunogenicity of multivalent SARS-CoV-2 vaccines....
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Compounds in traditional Chinese medicine herbs may inhibit SARS-CoV-2 infection

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Using computational methods, a team of researchers identified three compounds in traditional Chinese medicine that could be used against SARS-CoV-2. Source link...
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SARS-CoV-2 suppresses ACE2 activity in COVID-19 patients

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A recent study conducted by a team of international scientists has revealed that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of coronavirus...
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Around 10 SARS-CoV-2 virions per cell in human body, study finds

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A new study has found that there are about ten virus particles in each cell in the body. The research team from the Weizmann Institute...
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Identifying SARS-CoV-2 spike protein mutations resistant to antibodies

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Using a set of different monoclonal antibodies, researchers determined different mutations in the SARS-CoV-2 spike protein that leads to resistance. Understanding these resistant mutations is...
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Immune-evading variants can emerge in SARS-CoV-2, researchers warn

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An international team of researchers has shown that a mutation within severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus...
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5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

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Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is...
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ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

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A recent study published on the preprint server bioRxiv in October 2020 shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding to the human...
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Bat and pangolin coronavirus structure sheds light on SARS-CoV-2 evolution

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Researchers at Tsinghua University, Beijing, have conducted a study providing possible new insights into the evolution and cross-species transmission of severe acute respiratory syndrome coronavirus...
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Adaptations found in RNA secondary structure in genes of two proteins of SARS-CoV-2

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To investigate mutations in coronaviruses, a new study by scientists at Duke University and published on the preprint server bioRxiv, used a computational methodology, adaptiPhy,...
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S-pseudotyped VLPs offer promising COVID-19 vaccine platform

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A new study published on the preprint server bioRxiv* in September 2020 reports on a Moloney murine leukemia virus (MLV) platform that produces VLPs expressing...
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Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

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In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered...
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Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

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After screening more than 3,500 FDA-approved drugs and small molecules, researchers at the Chinese Academy of Sciences found that ceftazidime, an antibiotic approved for use...

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