Tag : Angiotensin-Converting Enzyme 2

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Adaptations found in RNA secondary structure in genes of two proteins of SARS-CoV-2

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To investigate mutations in coronaviruses, a new study by scientists at Duke University and published on the preprint server bioRxiv, used a computational methodology, adaptiPhy,...
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S-pseudotyped VLPs offer promising COVID-19 vaccine platform

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A new study published on the preprint server bioRxiv* in September 2020 reports on a Moloney murine leukemia virus (MLV) platform that produces VLPs expressing...
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Engineered, high-affinity ACE2 receptors neutralize SARS-CoV-2

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In a study published in the preprint server bioRxiv, researchers from the Kyoto Prefectural University of Medicine and Osaka University Japan, discuss how they engineered...
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Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

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After screening more than 3,500 FDA-approved drugs and small molecules, researchers at the Chinese Academy of Sciences found that ceftazidime, an antibiotic approved for use...
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Single-molecule imaging of SARS-CoV-2 spikes on virus particles

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Using single-molecule FRET analysis, a team of researchers has revealed how the different conformations of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein...
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Brain inflammation seen in fatal COVID-19 cases

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Now, a new study by researchers at the Barts Health NHS Trust and the University of Cambridge in the United Kingdom shows that some patients...
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Host gene editing main driving force of SARS-CoV-2 mutations

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A new study published on the aRxiv preprint server in September 2020 shows that the host immune response, mediated by two RNA editors, causes the...
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D614G spike mutation increases infectivity of SARS-CoV-2 and neutralization susceptibility

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As the COVID-19 pandemic progresses, it is crucial to track the viral changes in order to link the clinical and epidemiological features of the disease...
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Spike-based priming leads to high neutralizing activity in animal models

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A new report by researchers at the University of Melbourne and published on the preprint server bioRxiv in September 2020 reports on the use of...
Neurology

Study may help explain the symptoms and organs involved with SARS-CoV-2 infection

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A study of a gateway receptor for SARS-CoV-2 led by Walter Lukiw, PhD, Professor of Neuroscience, Neurology and Ophthalmology at LSU Health New Orleans’ Neuroscience...
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DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

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As COVID-19 continues to take a heavy toll on human health and life in many parts of the world, there is still no effective antiviral...
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Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

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A new study by researchers from the Scripps Research Institute and Novavax Inc. in the US affirms the structural integrity of the full-length SARS-CoV-2 spike...
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Novel short ACE2 isoform may influence SARS-CoV-2 susceptibility

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A study led by researchers at the University of Southampton, UK, has identified a novel short isoform of the full-length receptor that severe acute respiratory...
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New bivalent vaccine delivers robust cell-mediated and humoral immunity against SARS-CoV-2

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In a groundbreaking bioRxiv study, US researchers demonstrate the capability of next-generation bivalent human adenovirus serotype 5 (hAd5) vaccine for inducing both cellular and humoral...
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Scientists develop COVID-19 test to detect neutralizing antibodies with high sensitivity, specificity

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According to a study published in Nature Biotechnology, the sVNT is capable of detecting the functional neutralizing antibodies (NAbs) that can block the binding of...
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Novel antibody test for SARS-CoV-2

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A team of researchers in the United States have developed highly specific and sensitive assays that could improve understanding of the antibody response in coronavirus...
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SARS-CoV-2 infection modeling in iPSC-derived type 2 cells

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The most fatal form of COVID-19 disease is acute respiratory distress syndrome (ARDS), caused by direct viral injury as well as indirect noxious effects caused...
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Interesting study on which species may be infected by SARS-CoV-2

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The team from the University of Cambridge and the Pirbright Institute found that the Spike protein on SARS-CoV-2 engages with the host cell receptor angiotensin-converting...
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Direct structural link between SARS-CoV-2 and essential fatty acid

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Now, a new study published on the preprint server bioRxiv in June 2020 reports the discovery of a novel free fatty acid (FFA) binding pocket...
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ACE2 receptors for SARS-CoV-2 in human eye

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Since its emergence in Wuhan, China, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread rapidly over most of the world’s inhabited regions, causing...

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