anaphase
Meiosis with a single round of DNA replication and two successive rounds of chromosome segregation requires specific cyclins associated with cyclin-dependent kinases (CDKs) to ensure its fidelity. But how cyclins...
Read more- April 5, 2019
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- Tags: alignmentanaphasechromosomecompactionensuresfidelityInterchromosomalmitoticpromoting
Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood. Normal...
Read moreMeiosis poses unique challenges because two rounds of chromosome segregation must be executed without intervening DNA replication. Mammalian cells express numerous temporally regulated cyclins, but how these proteins collaborate to...
Read more- March 15, 2019
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- Tags: activationanaphaseCell cycle and cell divisionCellsCellular stress responsesCloningDNA damagehumanmitosisoriginatePathwaysRNA sequencingslowcyclingSmall interfering RNAsSpontaneouslystressresponsesubpopulations
by Mingwei Min, Sabrina L. Spencer Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed to give rise to drug...
Read more- September 7, 2018
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- Tags: adapteranaphasebindingcargoCdk1controlsdyneinG2Nde1Phosphorylation
Cytoplasmic dynein is involved in diverse cell cycle–dependent functions regulated by several accessory factors, including Nde1 and Ndel1. Little is known about the role of these proteins in dynein cargo...
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