anaphase

Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I

Meiosis with a single round of DNA replication and two successive rounds of chromosome segregation requires specific cyclins associated with cyclin-dependent kinases (CDKs) to ensure its fidelity. But how cyclins...

Read more
Mitotic chromosome alignment ensures mitotic fidelity by promoting interchromosomal compaction during anaphase

Chromosome alignment at the equator of the mitotic spindle is a highly conserved step during cell division; however, its importance to genomic stability and cellular fitness is not understood. Normal...

Read more
Cyclin B3 promotes anaphase I onset in oocyte meiosis

Meiosis poses unique challenges because two rounds of chromosome segregation must be executed without intervening DNA replication. Mammalian cells express numerous temporally regulated cyclins, but how these proteins collaborate to...

Read more
Spontaneously slow-cycling subpopulations of human cells originate from activation of stress-response pathways

by Mingwei Min, Sabrina L. Spencer Slow-cycling subpopulations exist in bacteria, yeast, and mammalian systems. In the case of cancer, slow-cycling subpopulations have been proposed to give rise to drug...

Read more
Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase

Cytoplasmic dynein is involved in diverse cell cycle–dependent functions regulated by several accessory factors, including Nde1 and Ndel1. Little is known about the role of these proteins in dynein cargo...

Read more