Tag : affinity

Pharma / Biotech

Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants.

Newsemia
Drug-Drug Interactions (DDIs) in Psychiatric Practice, Part 8: Relative Receptor Binding Affinity as a Way of Understanding the Differential Pharmacology of Currently Available Antidepressants. J...
Pharma / Biotech

The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model.

Newsemia
Related Articles The effect of ligand amount, affinity and internalization on PSMA-targeted imaging and therapy: A simulation study using a PBPK model. Sci Rep. 2019...
Cardiology

Affinity, binding kinetics and functional characterization of draflazine analogues for human Equilibrative Nucleoside Transporter 1 (SLC29A1).

Newsemia
Related Articles Affinity, binding kinetics and functional characterization of draflazine analogues for human Equilibrative Nucleoside Transporter 1 (SLC29A1). Biochem Pharmacol. 2019 Dec 09;:113747 Authors: Vlachodimou...
Pharma / Biotech

Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability.

Newsemia
Related Articles Structure-Activity Relationships for a series of bis(4-fluorophenyl)methyl)sulfinyl)alkyl alicyclic amines at the dopamine transporter: functionalizing the terminal nitrogen affects affinity, selectivity and metabolic stability....
Latest News

Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression

Newsemia
Adib, R; Montgomery, JM; Atherton, J; O’Regan, L; Richards, MW; Straatman, KR; Roth, D; … Fry, AM; + view all Adib, R; Montgomery, JM; Atherton,...
Biology

Emergence of a Chimeric Globin Pseudogene and Increased Hemoglobin Oxygen Affinity Underlie the Evolution of Aquatic Specializations in Sirenia

Newsemia
Abstract As limits on O2 availability during submergence impose severe constraints on aerobic respiration, the oxygen binding globin proteins of marine mammals are expected to...
Cardiology

Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo.

Newsemia
Related Articles Apelin peptides linked to anti-serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo. Basic Clin Pharmacol Toxicol....
AI/ML

Learning protein binding affinity using privileged information.

Newsemia
Related Articles Learning protein binding affinity using privileged information. BMC Bioinformatics. 2018 Nov 15;19(1):425 Authors: Abbasi WA, Asif A, Ben-Hur A, Minhas FUAA Abstract BACKGROUND:...
AI/ML

DeepDTA: deep drug-target binding affinity prediction.

Newsemia
Related Articles DeepDTA: deep drug-target binding affinity prediction. Bioinformatics. 2018 Sep 01;34(17):i821-i829 Authors: Öztürk H, Özgür A, Ozkirimli E Abstract Motivation: The identification of novel...
Pharma / Biotech

The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies.

Newsemia
Related Articles The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies. Methods Mol Biol. 2018;1827:479-489 Authors: Bowers PM, Boyle WJ, Damoiseaux R...

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