Tag : activation

Gastroenterology

6 NOVEL BRD4 INHIBITORS BLOCK THE PATHOLOGICAL ACTIVATION OF BRD4-NFκB SIGNALING AND SUPPRESS COLONIC INFLAMMATION IN IBD MOUSE MODELS

Newsemia
Ulcerative Colitis (UC) and Crohn’s Disease (CD) are two major types of inflammatory bowel disease (IBD), with recurrent symptoms and significant morbidity. Long-term persistence of...
Biology

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

Newsemia
by Iker Lamas, Laura Merlini, Aleksandar Vještica, Vincent Vincenzetti, Sophie G. Martin Local activity of the small GTPase Cdc42 is critical for cell polarization. Whereas...
Gastroenterology

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

Newsemia
Lay Summary: This study identified proteins that regulate genes that control activation of liver cells involved in development or resolution of fibrosis. These proteins might...
Biology

Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells

Newsemia
Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells Source link...
Biology

Enhanced translation expands the endo-lysosome size and promotes antigen presentation during phagocyte activation

Newsemia
by Victoria E. B. Hipolito, Jacqueline A. Diaz, Kristofferson V. Tandoc, Christian Oertlin, Johannes Ristau, Neha Chauhan, Amra Saric, Shannon Mclaughlan, Ola Larsson, Ivan Topisirovic,...

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