Spotlight on the January 21 issue
Spotlight on the January 21 issue Source link...
Category : Neurology
Homonymous hemiatrophy of ganglion cell layer from retrochiasmal lesions in the visual pathway
Objective To determine the temporal evolution, morphology, and frequency of macular ganglion cell atrophy in patients with retrochiasmal lesions of the visual pathway. Methods In...
Myasthenic crisis demanding mechanical ventilation: A multicenter analysis of 250 cases
Objective To determine demographic characteristics, clinical features, treatment regimens, and outcome of myasthenic crisis (MC) requiring mechanical ventilation (MV). Methods Analysis of patients who presented...
Author response: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
The data reviewed in our article1 raise the possibility that neuropathologic features in sporadic Parkinson disease (PD) and Alzheimer disease (AD) may be the result...
Reader response: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
In the article by Espay et al.,1 the abstract reads: “Whereas animal models…consistently support a pathogenic role of protein aggregation…human studies (do) not.” Source link...
Association of CD14 with incident dementia and markers of brain aging and injury
Objective To test the hypothesis that the inflammatory marker plasma soluble CD14 (sCD14) associates with incident dementia and related endophenotypes in 2 community-based cohorts. Methods...
Editors' note: Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases
Despite genetic data from families harboring APP mutations in Alzheimer disease (AD)—or SNCA gene multiplication in familial Parkinson disease (PD)—Dr. Espay et al. emphasized the...
Radiologic common data elements rates in pediatric mild traumatic brain injury
Objective The nosology for classifying structural MRI findings following pediatric mild traumatic brain injury (pmTBI) remains actively debated. Radiologic common data elements (rCDE) were developed...
Muscle MRI: A biomarker of disease severity in Duchenne muscular dystrophy? A systematic review
Objective To assess the evidence of a relationship between muscle MRI and disease severity in Duchenne muscular dystrophy (DMD). Methods We conducted a systematic review...
Education Research: A novel resident-driven neurology quality improvement curriculum
Objective To describe and assess the effectiveness of a neurology resident quality improvement curriculum focused on development of practical skills and project experience. Methods We...
Motor function decline correlates with behavioral impairment in C9orf72 mutation carriers
Expansion mutations in the C9orf72 gene are associated with clinical presentations of amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and mixed ALS-FTD features.1 Clinical phenotypes...