Dermatology

Targeted knockout of β-catenin in adult melanocyte stem cells using a mouse line, Dct::CreERT2, results in disrupted stem cell renewal and pigmentation defects





Melanocytes (Mc) are pigment-producing cells primarily found in the epidermis and hair follicles, where they transfer melanin to keratinocytes in the inner hair shaft (Colombo et al., 2011). Melanocyte progenitor cells, melanoblasts, arise from neural crest cells during embryogenesis, migrate along the embryo, and colonize the epidermis and hair follicles (Petit and Larue, 2016, Vandamme and Berx, 2019). In the hair follicle, mature Mc are found in the bulb, whereas melanocyte stem cells (McSCs) are found in the bulge (Nishimura et al., 2002, Osawa et al., 2005, Vandamme and Berx, 2019).

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