Regulatory T-cells but not IL-10 impair cell-mediated immunity in HPV+ hyperplastic epithelium

High-risk human papillomavirus (HPV) infection can induce cervical and other intraepithelial neoplasia and invasive cancers. A transgenic mouse expressing the HPV16 E7 oncoprotein driven by the K14 promotor (K14E7tg) exhibits epithelial hyperplasia and mimics many features of human HPV-related intraepithelial precancers. We have previously demonstrated that K14E7tg-mediated epithelial hyperplasia suppresses T helper type 1 (Th1) responses to intradermally delivered antigen and directs differentiation of CD4+ T-cells towards a Foxp3+ regulatory phenotype (Treg).

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