Dermatology

Drug Resistant Melanoma May Be Vulnerable to Inhibitors of Serine Synthesis





NRAS-driven melanomas frequently develop resistance to MAPK/extracellular signal–regulated kinase kinase inhibitors (MEKis), which limits their therapeutic utility. Nguyen et al. (2020) show that MEKi-resistant cells upregulate phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme in serine synthesis. Suppression of PHGDH rendered cells sensitive to MEKis, suggesting that PHGDH may be a therapeutic target for melanoma.

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