Pharma / Biotech

Functionalized DNA Enables Programming Exosomes/Vesicles for Tumor Imaging and Therapy.


Icon for Wiley Related Articles

Functionalized DNA Enables Programming Exosomes/Vesicles for Tumor Imaging and Therapy.

Small. 2019 11;15(47):e1903761

Authors: Fan Z, Xiao K, Lin J, Liao Y, Huang X

Abstract
Exosomes serve as significant information carriers that regulate important physiological and pathological processes. Herein, functionalized DNA is engineered to be a hinge that anchors quantum dots (QDs) onto the surface of exosomes, realizing a moderate and biocompatible labeling strategy. The QDs-labeled exosomes (exosome-DNA-QDs complex) can be swiftly engulfed by tumor cells, indicating that exosome-DNA-QDs can be applied as a specific agent for tumor labeling. Furthermore, the engineered artificial vesicles of M1 macrophages (M1mv) are constructed via a pneumatic liposome extruder. The results reveal that the individual M1mv can kill tumor cells and realize desirable biological treatment. To reinforce the antitumor efficacy of M1mv and the specificity of drug release, a target-triggered drug delivery system is constructed to realize a specific microRNA-responded delivery system for visual therapy of tumors. These strategies facilitate moderate labeling and functionalization of exosomes/vesicles and construct artificial drug-delivery vesicles that simultaneously possess biological treatment and chemotherapy functions, and thus have the potential to serve as a new paradigm for tumor labeling and therapy.

PMID: 31614072 [PubMed – indexed for MEDLINE]

Source link

Related posts

FtsZ inhibitors as a new genera of antibacterial agents.

Newsemia

FDA Gets Packed House for First CBD Hearing

Newsemia

DECITABINE injection, powder, lyophilized, for solution [Dr. Reddy's Laboratories Inc.]

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy

COVID-19

COVID-19 (Coronavirus) is a new illness that is having a major effect on all businesses globally LIVE COVID-19 STATISTICS FOR World