Brain-derived Neurotrophic Factor, Depressive Symptoms, and Somatic Comorbidity in Patients with Coronary Heart Disease.
Acta Neuropsychiatr. 2020 Sep 24;:1-22
Authors: Tschorn M, Kuhlmann SL, Rieckmann N, Beer K, Grosse L, Arolt V, Waltenberger J, Haverkamp W, Müller-Nordhorn J, Hellweg R, Ströhle A
OBJECTIVE: Depression and coronary heart disease (CHD) are highly comorbid conditions. Brain-derived neurotrophic factor (BDNF) plays an important role in cardiovascular processes. Depressed patients typically show decreased BDNF concentrations. We analyzed the relationship between BDNF and depression in a sample of patients with CHD, and additionally distinguished between cognitive-affective and somatic depression symptoms. We also investigated whether BDNF was associated with somatic comorbidity burden, acute coronary syndrome (ACS), or congestive heart failure (CHF).
METHODS: The following variables were assessed for 225 hospitalized patients with CHD: BDNF concentrations, depression (Patient Health-Questionnaire-9), somatic comorbidity (Charlson Comorbidity Index), CHF, ACS, platelet count, smoking status, antidepressant treatment.
RESULTS: Regression models revealed that BDNF was not associated with severity of depression: Although depressed patients (PHQ-9 score >7) had significantly lower BDNF concentrations compared to non-depressed patients (p=.04), this was not statistically significant after controlling for confounders (p=.15). Cognitive-affective symptoms and somatic comorbidity burden each closely missed a statistically significant association with BDNF concentrations (p=.08, p=.06, respectively). BDNF was reduced in patients with CHF (p=.02). There was no covariate-adjusted, significant association between BDNF and ACS.
CONCLUSION: Serum BDNF concentrations are associated with cardiovascular dysfunction. Somatic comorbidities should be considered when investigating the relationship between depression and BDNF.
PMID: 32967752 [PubMed – as supplied by publisher]