Cutaneous T-cell lymphoma (CTCL) is a group of non-Hodgkin lymphomas of skin-homing malignant T lymphocytes. In advanced stages, CTCL is incurable and often fatal (Arulogun et al., 2008), and blood involvement portends a poorer outcome (Agar et al., 2010). Overall response rates to systemic therapies are 30–50% and generally not durable. High-throughput screening has emerged as a rapid method for identification and prioritization of novel therapeutic compounds. Analysis of natural compounds and agents in ongoing clinical trials may accelerate opportunities for drug repurposing, synergy testing, and preclinical assessment for CTCL therapeutic potential.