Inhibition of the ERK/RSK kinase cascade limits Chlamydia trachomatis infection

Chlamydia trachomatis is the most common bacterial sexually transmitted infection worldwide. Azithromycin is effective in treating Chlamydia infection; however, resistance to this antibiotic is increasing, and it is important that new therapeutic strategies are developed. Here, we demonstrated that inhibitors targeting each kinase in the ERK/RSK cascade significantly decreased the size and number of inclusions, as well as the number of infectious progeny. The suppressive effects of the inhibitors were observed across the Chlamydia serotypes D, E, F, and L1 and across Hela, McCoy, and Vero host cells.

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