Postdoctoral position in nuclear and chromatin organisation in early development

A postdoc position is available in the Percharde lab at the MRC LMS in London, to investigate novel aspects of nuclear structure and chromatin organisation during early embryo development.


Position title:

3-year fixed term postdoctoral position funded by the MRC


About the position:

The Percharde lab at the MRC London Institute of Medical Science (MRC LMS) is looking to recruit a talented and highly-motivated postdoc to join our group. The Chromatin & Development group is a recently-established team focused on understanding the molecular events surrounding cell fate choices during early development.

Our lab investigates mechanisms of chromatin regulation in early mammalian development. We also study how chromatin regulation and other mechanisms are important for transposable element (TE) expression and function.

In this project, the candidate will investigate the importance of nuclear and nucleolar structure and organisation during early mouse development. Focusing on specific key proteins of interest in the lab, they will use a combination of mouse models and mouse embryonic stem cells (ESCs) to investigate the importance of nuclear and nucleolar structure and chromatin in genome organisation and gene regulation during embryonic development. The project will involve techniques routinely employed in the lab including imaging, genome-wide chromatin and transcriptomic analysis, molecular embryology and CRISPR/Cas9 manipulation.


Visit and

for more information about the lab. Closing date 11th Sept 2020


Candidate specifications:

Candidates should have a PhD or be in the final stages of completing one, and have a strong background in development, chromatin, or gene regulation, with this post ideally suiting someone with experience working with mouse embryos or ESCs looking to delve further into chromatin and developmental biology.



For full details of this post and to complete an online application, visit:  and upload your CV, the names and contacts of two scientific references, along with a cover letter stating why you are applying for this post (providing evidence against the requirements as per the Job Description and Person Specification).

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