Is radical ever too radical?

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are heterogeneous lesions with varied presentations, clinical courses, and prognoses. Some of these neoplasms display a very benign behavior, while others are extremely aggressive. Appropriately determining which patients will benefit from curative resection attempts is often difficult. While indications for resection of metastatic GEP-NENs continues to evolve, those with high grade (G3) lesions have not traditionally thought to benefit from curative intent surgery.

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