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STAT Plus: FDA urged to heighten safety warnings on common type 2 diabetes drugs

A consumer advocacy is urging the Food and Drug Administration to heighten warnings about a widely prescribed group of diabetes drugs known as SGLT-2 inhibitors, due to hundreds of cases of a potentially fatal reaction among people with type 1 diabetes, even though the medicines are not approved for those patients.

In a citizen’s petition being filed with the agency on Wednesday, Public Citizen argued that a “black box” warning, the most serious safety warning found in prescription drug labeling, should note SGLT-2 inhibitors can cause ketocacidosis. This is a serious complication of diabetes that occurs when the body produces high levels of blood acids called ketones and develops when the body fails to produce enough insulin.

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