Pharma / Biotech

Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats.


Related Articles

Pharmacokinetic and bioavailability studies of α-viniferin after intravenous and oral administration to rats.

J Pharm Biomed Anal. 2020 May 25;188:113376

Authors: Fan Y, Zhao L, Huang X, Jia Q, Wang W, Gao M, Jia X, Chang Y, Ouyang H, He J

Abstract
Alpha-viniferin is a trimer of resveratrol and has various pharmacological activities including anti-Alzheimer’s disease, anti-tuberculosis, anti-tumor, anti-inflammatory and anti-diabetic. To investigate the pharmacokinetic characteristics and absolute bioavailability of α-viniferin in rats, using naringenin as an internal standard (IS), a rapid HPLC-MS/MS method of 5 min complete run time was developed. The chromatographic separation of α-viniferin and naringenin were accomplished with Waters XBridge™ C18 column (2.1 mm × 100 mm, 3.5 μm) and the mobile phase were acetonitrile and 0.1 % formic acid at a flow rate of 0.3 mL/min. Plasma samples were pretreated by ethyl acetate. The negative ion mode with electrospray ionization (ESI) source was used for detecting the sample. Oral bioavailability of α-viniferin was 4.2 %. This study will be beneficial in better understanding the pharmacological properties and the further development of α-viniferin.

PMID: 32502955 [PubMed – as supplied by publisher]

Source link

Related posts

Ambulatory Pharmacists Make Their Mark in Specialty Care

Newsemia

ZYPITAMAG (Pitavastatin Magnesium) Tablet, Film Coated [Medicure International Inc]

Newsemia

TOPIRAMATE Tablet [Medsource Pharmaceuticals]

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy

COVID-19

COVID-19 (Coronavirus) is a new illness that is having a major effect on all businesses globally LIVE COVID-19 STATISTICS FOR World