Hunting for the Holy Grail in Colorectal Cancer

Beginning in the 1980s, various laboratories began to identify the specific molecular alterations in colorectal cancer (CRC), and the pace of discovery has continued unabated ever since. The breakthroughs began with the discovery of specific activating mutations of the KRAS oncogene in 19871 (and later, in BRAF2), followed by the concept of multistep carcinogenesis in 1988,3 the discovery of microsatellite instability (MSI) in 1992/1993,4,5 and later the CpG island methylator phenotype (CIMP) in 1999.

Source link

Related posts

Does Allergy Mitigate Appendicitis in Kids?


An individual participant data meta-analysis on metabolomics profiles for obesity and insulin resistance in European children


How can parental obesity promote OA across generations?


This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy


COVID-19 (Coronavirus) is a new illness that is having a major effect on all businesses globally LIVE COVID-19 STATISTICS FOR World