Tobacco smoking and the reduced risk of Parkinson disease: A puzzle of 60 years

Parkinson disease (PD) is a progressive neurodegenerative disorder of the motor system that affects 6.2 million people globally.1 The exact pathogenic mechanism underlying PD remains unclear. Although the current drugs for PD can relieve disease symptoms to some extent, the efficacy duration is limited, and it is hard to cure, halt, or reverse the disease.2 Therefore, the identification of modifiable risk factors is imperative for the prevention of PD.

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