Combining rivaroxaban with aspirin in stable atherosclerotic vascular disease: clinical evidence from the COMPASS study

Peripheral artery disease in the UK - unmet needsThis article will contribute to a ‘Learning with reflection’ CPD activity.

The COMPASS (Cardiovascular Outcomes for People Using Anticoagulation Strategies) trial was a double-dummy, double-blind, multicentre, randomised clinical trial in patients with stable atherosclerotic vascular disease (sponsored by Bayer). Patients were randomised to one of three treatment groups: low-dose (2.5 mg twice daily) rivaroxaban plus aspirin (100 mg), higher dose (5 mg twice daily) rivaroxaban alone, or aspirin (100 mg) alone. The primary outcome, a composite of cardiovascular death, stroke, or myocardial infarction, occurred in fewer patients randomised to rivaroxaban plus aspirin, compared with aspirin alone. The study was terminated early due to the superiority of the combination therapy after a mean follow-up of 23 months. Major bleeding occurred more frequently in the combination therapy group. Twice-daily rivaroxaban 5 mg monotherapy did not significantly lower the risk of major adverse cardiovascular events versus aspirin alone (HR 0.90, p=0.12) and resulted in a significantly higher risk of major bleeding.

Source link

Related posts

Women and Heart Disease


QRS-T Angle Improves Diagnostic Accuracy of NSTEMI, Predicts Mortality Risk


Donor and Recipient Risk Factor Analysis of Inferior Post-Heart Transplantation Outcome in the Era of Durable Mechanical Assist Devices.


This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy


COVID-19 (Coronavirus) is a new illness that is having a major effect on all businesses globally LIVE COVID-19 STATISTICS FOR World