Pharma / Biotech

Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines.


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Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines.

Recent Pat Drug Deliv Formul. 2020 Mar 24;:

Authors: Singh A, Kharb V, Saharan VA

Abstract
Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve/disintegrate quickly leading to fast distribution of active ingredient at site of administration thereby provides ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. Objective of this review is to explore the application of various FDDFs to deliver extracts, herbal powders, natural active compounds and nutraceuticals. Scholarly literature from Pubmed, google scholar and directory of open access journals was retrieved. Patent search for US patent database, WIPO’s Patentscope, Espacenet and google patents was performed. Collected literature was screened and only such researches/inventions involving use of FDDFs for delivery of herbal actives and natural active compounds are reported. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic system and traditional Chinese medicine have embraced FDDFs for delivery of active compounds. Most of the patents in this area are originating from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. Dose of active compound, size of dosage forms. Standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals.

PMID: 32208129 [PubMed – as supplied by publisher]

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