Cardiology

Statins are associated with new onset type 2 diabetes mellitus (T2DM) in Medicare patients ≥65 years.


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Statins are associated with new onset type 2 diabetes mellitus (T2DM) in Medicare patients ≥65 years.

Diabetes Metab Res Rev. 2020 Mar 12;:e3310

Authors: Tangelloju S, Little BB, Esterhay RJ, Brock G, LaJoie S

Abstract
OBJECTIVE: To evaluate the association of statins and co-morbidities with new onset type 2 diabetes mellitus (T2DM) in patients 65 years and older.
METHODS: This retrospective study used de-identified administrative healthcare claims and enrollment data from a Medicare Advantage Prescription Drug (MAPD) health plan offered by a large multistate healthcare company. The plan covered >2.4 million individuals, of whom >1.7 million individuals were ≥ 65 years. Of these, 265 554 individuals had continuous MAPD enrollment January 2008 to December 2015. The unadjusted model assessed demographic, pharmacy, and T2DM co-morbidities as covariates. Significant variables (P < 0.05) in the unadjusted model were then included in the adjusted model. The adjusted model used Cox proportional hazards to evaluate covariate effects. Matched propensity score analysis was used to analyze the association of statins and T2DM onset.
RESULTS: The cumulative rate of diagnosed T2DM onset in the study cohort was 4.82% (4314/89390). Annualized incidence of T2DM diagnosis was 0.82%, 0.88%, 1.04% and 2.09% in 2012, 2013, 2014 and 2015, respectively. T2DM onset was associated with male sex, non-white (African American or Hispanic ethnicity), statin use, hypertension, hyperlipidemia, heart failure, lower limb ulceration, atherosclerosis, other retinopathy, angina pectoris, poor vision and blindness, and absence ischemic heart disease (IHD). Matched propensity score analysis showed that statin use was significantly associated with T2DM onset (Odds Ratio = 1.26, 95% Confidence Interval: 1.12-1.41, P < 0.0001) in the adjusted model.
CONCLUSIONS: Analyses indicated that statin usage was associated with new onset T2DM after adjusting for covariates. This article is protected by copyright. All rights reserved.

PMID: 32162770 [PubMed – as supplied by publisher]

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