Acid-suppression medication may increase the odds for colonization by multidrug-resistant microorganisms, according to a meta-analysis published in JAMA Internal Medicine.
Roel P.J. Willems, MD, of the department of medical microbiology and infection at Amsterdam UMC, and colleagues wrote that use of acid suppressors is on the rise, with proton pump inhibitor use alone doubling in the United States between 1999 and 2012. This has led to concerns about how these drugs alter the gut microbiome.
“Whether acid suppression facilitates colonization and infection with [multidrug-resistant