Gastroenterology

12 A FUNCTIONAL TL1A/DR3 SYSTEM IS CRUCIAL FOR OPTIMAL GENERATION OF PATHOGENIC TH9 CELLS IN MURINE CROHN'S DISEASE-LIKE ILEITIS




Despite numerous therapeutic advancements, inflammatory bowel disease (IBD) remains a major health burden due to the inefficiency of conventional therapies. We recently demonstrated the role of death receptor 3 (DR3), a member of the tumor necrosis factor receptor (TNFR) superfamily and receptor for the cytokine TL1A, in regulating the balance between effector [T helper type 1 (TH)1,TH2,TH17] and regulatory T cells during murine Crohn’s disease (CD)-like ileitis. New evidence suggests a potential role of IL-9-secreting TH9 cells in the pathogenesis of IBD.

Source link




Related posts

College Bribery Scandal Snags Doc; Genitals on Instagram; Smollett EHR Snooping

Newsemia

Neonatal exposures and risk of IBD – when does the clock starts ticking?

Newsemia

Full-length transcript amplification and sequencing as universal method to test mRNA integrity and biallelic expression in mismatch repair genes

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy