Adipose tissue-liver cross talk in the control of whole-body metabolism: implications in non-alcoholic fatty liver disease

Adipose tissue and the liver play a significant role in the regulation of whole body energy homeostasis, but they have not evolved to cope with the continuous, chronic, nutrient surplus seen in obesity. In this review, we detail how prolonged metabolic stress leads to adipose tissue dysfunction, inflammation and adipokine release that results in increased lipid flux to the liver. Overall, the upshot of hepatic fat accumulation alongside an insulin resistant state, is that hepatic lipid enzymatic pathways are modulated and overwhelmed, resulting in the selective build-up of toxic lipid species, which worsens the pro-inflammatory and pro-fibrotic shift observed in NASH.

Source link

Related posts

Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy


Study: Hepatitis C+ Donor Hearts Just as Good


The multidisciplinary management of rectal cancer


This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy