Cardiology

Lesion Configuration Effect on Stroke-Related Cardiac Autonomic Dysfunction.



Related Articles

Lesion Configuration Effect on Stroke-Related Cardiac Autonomic Dysfunction.

Brain Res. 2020 Feb 05;:146711

Authors: Raphaely-Beer N, Katz-Leurer M, Soroker N

Abstract
BACKGROUND: Autonomic nervous system (ANS) malfunction is a common sequel of stroke. The impact of lesion configuration on the expression of stroke-related ANS malfunction is largely unknown.
OBJECTIVE: To examine the relationship between stroke location and ANS malfunction, as reflected in cardiac rhythm control.
METHODS: 25 patients in the subacute phase post first-ever ischemic stroke were recruited for the study. Heart rate monitor (RS800CX) was used to record RR intervals analyzed as heart rate variability (HRV) parameters. Lesion data derived from follow-up CT scans of the brain was used for voxel-based lesion symptom mapping (VLSM) analysis (MEDx software, Medical Numerics) to identify voxels of the normalized brain where damage exerts a significant impact on the HRV scores.
RESULTS AND CONCLUSION: ANS control of the cardiac rhythm, as expressed in the HRV, was affected by damage to a large array of cortical and subcortical structures in the right hemisphere. In the left hemisphere only damage confined to a small set of subcortical structures was shown to exert a significant impact on the recorded HRV measures. In addition, VLSM analysis disclosed a different pattern of cerebral control over two widely used standard time-dependent measures of the HRV – SDNN and RMSSD, with the former being sensitive to damage in a much larger array of structures in both hemispheres.

PMID: 32035088 [PubMed – as supplied by publisher]

Source link




Related posts

Sodium Fluoride PET and Aortic Bioprosthetic Valve Degeneration: Implications for Patient Diagnosis, Management, and Treatment

Newsemia

Three Factors Combined Predict Futility of Emergency Coronary Angiography After Out-of-Hospital Cardiac Arrest

Newsemia

Intronic Polymorphisms in Gene of Second Heart Field as Risk Factors for Human Congenital Heart Disease in a Chinese Population.

Newsemia

This website uses cookies to improve your experience. We'll assume you're ok with this, but you can opt-out if you wish. Accept Read More

Privacy & Cookies Policy