Reader response: Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine

The article by Domínguez et al.1 is a milestone article in the evolution toward understanding migraine, especially chronic migraine. Of course, it is worth appreciation, but we must travel miles further to evaluate in this direction. There is impairment of iron homeostasis in migraineurs,2 but it remains unclear whether iron accumulation has a causative role or is a result of chronic migraine headache as assumed by an earlier study.2

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