Gastroenterology

Antisense oligonucleotide therapy for triglyceride reduction shows positive top-line results




Akcea Therapeutics and Ionis Pharmaceuticals announced that a phase 2 study of AKCEA-ANGPTL3-LRx for the treatment of patients with hypertriglyceridemia, type 2 diabetes and nonalcoholic fatty liver disease met its primary endpoint of significant triglyceride lowering.
The study also met several secondary endpoints with a favorable tolerability and safety profile, according to a press release from the companies.
AKCEA-ANGPTL3-LRx is an antisense oligonucleotide therapy that reduces production of angiopoietin-like 3 (ANGPTL3) protein in the liver.
The phase 2 study aimed to evaluate the efficacy

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