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Tweaking how CAR-T therapy kills tumors could stop a dangerous side effect, study finds

As every trauma surgeon knows, there are messy bullet wounds and there are neat ones, and the former cause incomparably more trouble. If a team of scientists in China is right, the same principle may explain why the genetically engineered CAR-T cells that have been so successful against some leukemias and lymphomas often cause a violent and even life-threatening immune reaction.

The problem, the researchers reported on Friday, is that CAR-Ts attack and kill cancer cells in the messiest way biologists have ever seen.

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