Oncogenic Mutations in Armadillo Repeats 5 and 6 of β-catenin Reduce Binding to APC, Increasing Signaling and Transcription of Target Genes

The β-catenin signaling pathway is one of the most commonly deregulated pathways in cancer cells. Amino-acid substitutions within armadillo repeats 5 and 6 (K335, W383, and N387) of β-catenin are found in several tumor types, including liver tumors. We investigated the mechanisms by which these substitutions increase signaling and the effects on liver carcinogenesis in mice.

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