Neurology

Severe thrombocytopenia during Natalizumab therapy: A case report

Natalizumab (NTZ) is a humanized monoclonal antibody that targets alpha4-integrins reducing leukocytes trafficking across the blood brain barrier [9]. Although NTZ has an unquestionable efficacy on disease activity in relapsing-remitting Multiple Sclerosis (RRMS), its safety profile has been questioned. Progressive multifocal leukoencephalopathy is the most frightening adverse event during NTZ-treatment [10]. However other NTZ-induced side effects have been described, including haematological disorders, particularly frequent in the newborns after NTZ-exposure during pregnancy [5].

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