Gastroenterology

Identification and validation of microRNA profiles in fecal samples for detection of colorectal cancer

Screening for colorectal cancer (CRC) is effective in average-risk population. The most extended strategy in organized programs involves the fecal immunochemical test, which is limited by low sensitivity for detection of advanced adenomas (AAs). We aimed to identify microRNA (miRNA) signatures in fecal samples that identify patients with AAs or CRC and might be used in non-invasive screening.

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