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Pre-salvage RT PSA predictive of hormone therapy benefit with salvage RT for recurrent prostate cancer

Initial results of NRG Oncology Clinical Trial RTOG 9601 in men with biochemically recurrent prostate cancer receiving salvage radiotherapy (SRT) demonstrated improvement in OS from the addition of long-term hormone therapy to SRT. However, a secondary analysis indicates that all patients do not benefit and the addition of long-term anti-androgen therapy did not improve overall survival (OS) rates and could increase other-cause mortality (OCM) for some patients depending on pre-treatment PSA level. Data now shows that pre-SRT prostate-specific antigen (PSA) was a prognostic and predictive biomarker in determining the benefit of the addition of anti-androgen therapy to early SRT. These results were presented during the plenary session of the American Society of Radiation Oncology’s (ASTRO) Annual Meeting in September 2019. The abstract is one of four abstracts chosen from over 3,000 submitted abstracts for the plenary session.

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